The emerging landscape of single-molecule protein sequencing technologies
Single-cell profiling methods have had a profound impact on the understanding of cellular
heterogeneity. While genomes and transcriptomes can be explored at the single-cell level …
heterogeneity. While genomes and transcriptomes can be explored at the single-cell level …
Engineering biological nanopore approaches toward protein sequencing
Biotechnological innovations have vastly improved the capacity to perform large-scale
protein studies, while the methods we have for identifying and quantifying individual proteins …
protein studies, while the methods we have for identifying and quantifying individual proteins …
Solid-state nanopore systems: from materials to applications
Ion transport and hydrodynamic flow through nanometer-sized channels (nanopores) have
been increasingly studied owing to not only the fundamental interest in the abundance of …
been increasingly studied owing to not only the fundamental interest in the abundance of …
Hydrophobically gated memristive nanopores for neuromorphic applications
Signal transmission in the brain relies on voltage-gated ion channels, which exhibit the
electrical behaviour of memristors, resistors with memory. State-of-the-art technologies …
electrical behaviour of memristors, resistors with memory. State-of-the-art technologies …
Nanopores in graphene and other 2D materials: a decade's journey toward sequencing
Nanopore techniques offer a low-cost, label-free, and high-throughput platform that could be
used in single-molecule biosensing and in particular DNA sequencing. Since 2010 …
used in single-molecule biosensing and in particular DNA sequencing. Since 2010 …
Portable nanopore-sequencing technology: Trends in development and applications
P Chen, Z Sun, J Wang, X Liu, Y Bai, J Chen… - Frontiers in …, 2023 - frontiersin.org
Sequencing technology is the most commonly used technology in molecular biology
research and an essential pillar for the development and applications of molecular biology …
research and an essential pillar for the development and applications of molecular biology …
Protein Sizing with 15 nm Conical Biological Nanopore YaxAB
S Straathof, G Di Muccio, M Yelleswarapu… - ACS …, 2023 - ACS Publications
Nanopores are promising single-molecule tools for the electrical identification and
sequencing of biomolecules. However, the characterization of proteins, especially in real …
sequencing of biomolecules. However, the characterization of proteins, especially in real …
Analytical techniques for multiplex analysis of protein biomarkers
Introduction The importance of biomarkers for pharmaceutical drug development and clinical
diagnostics is more significant than ever in the current shift toward personalized medicine …
diagnostics is more significant than ever in the current shift toward personalized medicine …
Controlled movement of ssDNA conjugated peptide through Mycobacterium smegmatis porin A (MspA) nanopore by a helicase motor for peptide sequencing …
Z Chen, Z Wang, Y Xu, X Zhang, B Tian, J Bai - Chemical science, 2021 - pubs.rsc.org
The lack of an efficient, low-cost sequencing method has long been a significant bottleneck
in protein research and applications. In recent years, the nanopore platform has emerged as …
in protein research and applications. In recent years, the nanopore platform has emerged as …
Electroosmosis in nanopores: computational methods and technological applications
Electroosmosis is a fascinating effect where liquid motion is induced by an applied electric
field. Counter ions accumulate in the vicinity of charged surfaces, triggering a coupling …
field. Counter ions accumulate in the vicinity of charged surfaces, triggering a coupling …