Advancement in solubilization approaches: A step towards bioavailability enhancement of poorly soluble drugs

L Kumari, Y Choudhari, P Patel, GD Gupta, D Singh… - Life, 2023 - mdpi.com
A drug's aqueous solubility is defined as the ability to dissolve in a particular solvent, and it
is currently a major hurdle in bringing new drug molecules to the market. According to some …

Kinetic modeling to explain the release of medicine from drug delivery systems

M Askarizadeh, N Esfandiari, B Honarvar… - ChemBioEng …, 2023 - Wiley Online Library
Proper medication dissolution must be ensured when develo** or manufacturing a new
solid dosage form. Quantitative analyses performed in dissolution or release tests become …

[HTML][HTML] Non-ionic surfactants for stabilization of polymeric nanoparticles for biomedical uses

H Cortés, H Hernández-Parra, SA Bernal-Chávez… - Materials, 2021 - mdpi.com
Surfactants are essential in the manufacture of polymeric nanoparticles by emulsion
formation methods and to preserve the stability of carriers in liquid media. The deposition of …

Immunological and toxicological considerations for the design of liposomes

CT Inglut, AJ Sorrin, T Kuruppu, S Vig, J Cicalo… - Nanomaterials, 2020 - mdpi.com
Liposomes hold great potential as gene and drug delivery vehicles due to their
biocompatibility and modular properties, coupled with the major advantage of attenuating …

Nanocrystals of poorly soluble drugs: drug bioavailability and physicochemical stability

MR Gigliobianco, C Casadidio, R Censi, P Di Martino - Pharmaceutics, 2018 - mdpi.com
Many approaches have been developed over time to overcome the bioavailability limitations
of poorly soluble drugs. With the advances in nanotechnology in recent decades, science …

[HTML][HTML] Hyperthermia and smart drug delivery systems for solid tumor therapy

ALB Seynhaeve, M Amin, D Haemmerich… - Advanced Drug Delivery …, 2020 - Elsevier
Chemotherapy is a cornerstone of cancer therapy. Irrespective of the administered drug, it is
crucial that adequate drug amounts reach all cancer cells. To achieve this, drugs first need …

Chitosan: An overview of biological activities, derivatives, properties, and current advancements in biomedical applications.

GI Edo, E Yousif, MH Al-Mashhadani - Carbohydrate Research, 2024 - Elsevier
The second and most often utilized natural polymer is chitosan (CS), a naturally existing
amino polysaccharide that is produced by deacetylating chitin. Numerous applications have …

Scale-up of pharmaceutical spray drying using scale-up rules: A review

S Poozesh, E Bilgili - International Journal of Pharmaceutics, 2019 - Elsevier
Spray drying is one of the widely used manufacturing processes in pharmaceutical industry.
While there are voluminous experimental studies pertaining to the impact of various process …

[HTML][HTML] Temperature-sensitive polymers to promote heat-triggered drug release from liposomes: Towards bypassing EPR

M Amin, T Lammers, TLM Ten Hagen - Advanced Drug Delivery Reviews, 2022 - Elsevier
Heat-triggered drug release from temperature-sensitive nanocarriers upon the application of
mild hyperthermia is a promising approach to achieve site-specific delivery of drugs. The …

[HTML][HTML] Development of dissolving microneedles for intradermal delivery of the long-acting antiretroviral drug bictegravir

C Zhang, LK Vora, IA Tekko, F Volpe-Zanutto… - International journal of …, 2023 - Elsevier
Oral administration and intramuscular (IM) injection are commonly recommended options for
human immunodeficiency virus (HIV) treatment. However, poor patient compliance due to …