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Advancement in solubilization approaches: A step towards bioavailability enhancement of poorly soluble drugs
L Kumari, Y Choudhari, P Patel, GD Gupta, D Singh… - Life, 2023 - mdpi.com
A drug's aqueous solubility is defined as the ability to dissolve in a particular solvent, and it
is currently a major hurdle in bringing new drug molecules to the market. According to some …
is currently a major hurdle in bringing new drug molecules to the market. According to some …
Kinetic modeling to explain the release of medicine from drug delivery systems
M Askarizadeh, N Esfandiari, B Honarvar… - ChemBioEng …, 2023 - Wiley Online Library
Proper medication dissolution must be ensured when develo** or manufacturing a new
solid dosage form. Quantitative analyses performed in dissolution or release tests become …
solid dosage form. Quantitative analyses performed in dissolution or release tests become …
[HTML][HTML] Non-ionic surfactants for stabilization of polymeric nanoparticles for biomedical uses
Surfactants are essential in the manufacture of polymeric nanoparticles by emulsion
formation methods and to preserve the stability of carriers in liquid media. The deposition of …
formation methods and to preserve the stability of carriers in liquid media. The deposition of …
Immunological and toxicological considerations for the design of liposomes
Liposomes hold great potential as gene and drug delivery vehicles due to their
biocompatibility and modular properties, coupled with the major advantage of attenuating …
biocompatibility and modular properties, coupled with the major advantage of attenuating …
Nanocrystals of poorly soluble drugs: drug bioavailability and physicochemical stability
Many approaches have been developed over time to overcome the bioavailability limitations
of poorly soluble drugs. With the advances in nanotechnology in recent decades, science …
of poorly soluble drugs. With the advances in nanotechnology in recent decades, science …
[HTML][HTML] Hyperthermia and smart drug delivery systems for solid tumor therapy
Chemotherapy is a cornerstone of cancer therapy. Irrespective of the administered drug, it is
crucial that adequate drug amounts reach all cancer cells. To achieve this, drugs first need …
crucial that adequate drug amounts reach all cancer cells. To achieve this, drugs first need …
Chitosan: An overview of biological activities, derivatives, properties, and current advancements in biomedical applications.
The second and most often utilized natural polymer is chitosan (CS), a naturally existing
amino polysaccharide that is produced by deacetylating chitin. Numerous applications have …
amino polysaccharide that is produced by deacetylating chitin. Numerous applications have …
Scale-up of pharmaceutical spray drying using scale-up rules: A review
Spray drying is one of the widely used manufacturing processes in pharmaceutical industry.
While there are voluminous experimental studies pertaining to the impact of various process …
While there are voluminous experimental studies pertaining to the impact of various process …
[HTML][HTML] Temperature-sensitive polymers to promote heat-triggered drug release from liposomes: Towards bypassing EPR
Heat-triggered drug release from temperature-sensitive nanocarriers upon the application of
mild hyperthermia is a promising approach to achieve site-specific delivery of drugs. The …
mild hyperthermia is a promising approach to achieve site-specific delivery of drugs. The …
[HTML][HTML] Development of dissolving microneedles for intradermal delivery of the long-acting antiretroviral drug bictegravir
Oral administration and intramuscular (IM) injection are commonly recommended options for
human immunodeficiency virus (HIV) treatment. However, poor patient compliance due to …
human immunodeficiency virus (HIV) treatment. However, poor patient compliance due to …