Cancer is a complex disease resulting from abnormal cell growth that is induced by a
number of genetic and environmental factors. The tumor microenvironment (TME), which …

More than two decades ago, experiments on the antiviral mechanisms of IFNs led to the
discovery of JAKs and their downstream effectors, the STAT proteins. This pathway has …

Abstract BACKGROUND Extracellular RNAs (exRNAs) in human body fluids are emerging
as effective biomarkers for detection of diseases. Saliva, as the most accessible and …

Abstract microRNAs (miRNAs) are a large class of small non-coding RNAs which post-
transcriptionally regulate the expression of a large fraction of all animal genes and are …

Summary The c-Myc HLH-bZIP protein has been implicated in physiological or pathological
growth, proliferation, apoptosis, metabolism, and differentiation at the cellular, tissue, or …

Immune imbalance of T lymphocyte subsets is a hallmark of psoriasis, but the molecular
mechanisms underlying this aspect of psoriasis pathology are poorly understood. Here, we …

Super-enhancers are an emerging subclass of regulatory regions controlling cell identity
and disease genes. However, their biological function and impact on miRNA networks are …

Toll-like receptor (TLR) signalling must be tightly regulated to avoid excessive inflammation
and to allow for tissue repair and the return to homeostasis after infection and tissue injury …

For acutely lethal influenza infections, the relative pathogenic contributions of direct viral
damage to lung epithelium versus dysregulated immunity remain unresolved. Here, we take …

Abstract CD4+ T helper (TH) cells regulate appropriate cellular and humoral immune
responses to a wide range of pathogens and are central to the success of vaccines …