CD69 is an early leukocyte activation molecule expressed at sites of chronic inflammation.
The precise role of CD69 in immunity has not been elucidated owing to the absence of a …

Natural killer (NK) cells are innate lymphocytes that play a critical role in early host defense
against viruses. Through their cytolytic capacity and generation of cytokines and …

Recent evidence indicates that natural killer (NK) cells can negatively regulate T-cell
responses, but the mechanisms behind this phenomenon as a consequence of NK–T-cell …

It is important to understand which molecules are relevant for linking innate and adaptive
immune cells. In this study, we show that OX40 ligand is selectively induced on IL-2, IL-12 …

A high risk of local relapse is the main challenge of HER2+ breast cancer after breast-
conserving surgery. We aimed to develop a long-acting delivery system for Herceptin, a …

The underlying mechanisms of tumor-induced immune suppression need to be fully
understood. Regulatory T (Treg) cells have been shown to play an important role in tumor …

Exosomes are a class of nanovesicles formed and released through the late endosomal
compartment and represent an important mode of intercellular communication. The ability of …

Viral infections often gain access to the body of their host by exploiting areas of natural
vulnerability, such as the semipermeable surfaces of mucosal tissues which are adapted for …

Intracellular heat shock proteins (HSP) function as molecular chaperones, they support
folding and transport mechanisms of other proteins under physiological conditions and …

Substantial evidence indicates that immune activation at stroma can be rerouted in a tumor-
promoting direction. CD69 is an immunoregulatory molecule expressed by early-activated …