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A review on structural, non-structural, and accessory proteins of SARS-CoV-2: Highlighting drug target sites
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of
COVID-19, is a highly transmittable and pathogenic human coronavirus that first emerged in …
COVID-19, is a highly transmittable and pathogenic human coronavirus that first emerged in …
Methodology-centered review of molecular modeling, simulation, and prediction of SARS-CoV-2
Despite tremendous efforts in the past two years, our understanding of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), virus–host interactions, immune …
respiratory syndrome coronavirus 2 (SARS-CoV-2), virus–host interactions, immune …
A stapled lipopeptide platform for preventing and treating highly pathogenic viruses of pandemic potential
GH Bird, JJ Patten, W Zavadoski, N Barucci… - Nature …, 2024 - nature.com
The continued emergence of highly pathogenic viruses, which either thwart immune-and
small molecule-based therapies or lack interventions entirely, mandates alternative …
small molecule-based therapies or lack interventions entirely, mandates alternative …
Peptide-Based Strategies Against SARS-CoV-2 Attack: An Updated In Silico Perspective
G Moroy, P Tuffery - Frontiers in Drug Discovery, 2022 - frontiersin.org
Because of its scale and suddenness, the SARS-CoV-2 pandemic has created an
unprecedented challenge in terms of drug development. Apart from being natural …
unprecedented challenge in terms of drug development. Apart from being natural …
Large scale peptide screening against main protease of SARS CoV‐2
MJ Uddin, H Akhter, U Chowdhury… - Journal of …, 2023 - Wiley Online Library
The COVID‐19 pandemic has been a public health emergency, with deadly forms constantly
emerging around the world, highlighting the dire need for highly effective antiviral …
emerging around the world, highlighting the dire need for highly effective antiviral …
Structure and dynamics of whole-sequence homology model of ORF3a protein of SARS-CoV-2: An insight from microsecond molecular dynamics simulations
The ORF3a is a large accessory protein in severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), which plays an important role in virulence and viral replication; especially in …
(SARS-CoV-2), which plays an important role in virulence and viral replication; especially in …
Structural and functional effects of the L84S mutant in the SARS-COV-2 ORF8 dimer based on microsecond molecular dynamics study
The L84S mutation has been observed frequently in the ORF8 protein of SARS-CoV-2,
which is an accessory protein involved in various important functions such as virus …
which is an accessory protein involved in various important functions such as virus …
Recombinant protein micelles to block transduction by SARS-CoV-2 pseudovirus
The continuing emergence of variants of the SARS-CoV-2 virus requires the development of
modular molecular therapies. Here, we engineered a recombinant amphiphilic protein …
modular molecular therapies. Here, we engineered a recombinant amphiphilic protein …
Potential antiviral peptides against the nucleoprotein of SARS-CoV-2
I Mahdi, H Yeasmin, I Hossain, RM Badhan, MA Ali… - Chemical Papers, 2023 - Springer
Nucleoprotein is a conserved structural protein of SARS-CoV-2, which is involved in several
functions, including replication, packaging, and transcription. In this research, 21 antiviral …
functions, including replication, packaging, and transcription. In this research, 21 antiviral …
Unraveling the impact of ORF3a Q57H mutation on SARS-CoV-2: insights from molecular dynamics
ORF3a is a conserved accessory protein of SARS-CoV-2, linked to viral infection and
pathogenesis, with acquired mutations at various locations. Previous studies have shown …
pathogenesis, with acquired mutations at various locations. Previous studies have shown …