A review on structural, non-structural, and accessory proteins of SARS-CoV-2: Highlighting drug target sites

MJ Islam, NN Islam, MS Alom, M Kabir, MA Halim - Immunobiology, 2023 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of
COVID-19, is a highly transmittable and pathogenic human coronavirus that first emerged in …

Methodology-centered review of molecular modeling, simulation, and prediction of SARS-CoV-2

K Gao, R Wang, J Chen, L Cheng, J Frishcosy… - Chemical …, 2022 - ACS Publications
Despite tremendous efforts in the past two years, our understanding of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), virus–host interactions, immune …

A stapled lipopeptide platform for preventing and treating highly pathogenic viruses of pandemic potential

GH Bird, JJ Patten, W Zavadoski, N Barucci… - Nature …, 2024 - nature.com
The continued emergence of highly pathogenic viruses, which either thwart immune-and
small molecule-based therapies or lack interventions entirely, mandates alternative …

Peptide-Based Strategies Against SARS-CoV-2 Attack: An Updated In Silico Perspective

G Moroy, P Tuffery - Frontiers in Drug Discovery, 2022 - frontiersin.org
Because of its scale and suddenness, the SARS-CoV-2 pandemic has created an
unprecedented challenge in terms of drug development. Apart from being natural …

Large scale peptide screening against main protease of SARS CoV‐2

MJ Uddin, H Akhter, U Chowdhury… - Journal of …, 2023 - Wiley Online Library
The COVID‐19 pandemic has been a public health emergency, with deadly forms constantly
emerging around the world, highlighting the dire need for highly effective antiviral …

Structure and dynamics of whole-sequence homology model of ORF3a protein of SARS-CoV-2: An insight from microsecond molecular dynamics simulations

S Akter, MJ Islam, MA Ali, M Zakaria Tashrif… - Journal of …, 2024 - Taylor & Francis
The ORF3a is a large accessory protein in severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), which plays an important role in virulence and viral replication; especially in …

Structural and functional effects of the L84S mutant in the SARS-COV-2 ORF8 dimer based on microsecond molecular dynamics study

S Islam, MR Parves, MJ Islam, MA Ali… - Journal of …, 2024 - Taylor & Francis
The L84S mutation has been observed frequently in the ORF8 protein of SARS-CoV-2,
which is an accessory protein involved in various important functions such as virus …

Recombinant protein micelles to block transduction by SARS-CoV-2 pseudovirus

R Chattaraj, CY Kim, D Lee, DA Hammer - ACS nano, 2022 - ACS Publications
The continuing emergence of variants of the SARS-CoV-2 virus requires the development of
modular molecular therapies. Here, we engineered a recombinant amphiphilic protein …

Potential antiviral peptides against the nucleoprotein of SARS-CoV-2

I Mahdi, H Yeasmin, I Hossain, RM Badhan, MA Ali… - Chemical Papers, 2023 - Springer
Nucleoprotein is a conserved structural protein of SARS-CoV-2, which is involved in several
functions, including replication, packaging, and transcription. In this research, 21 antiviral …

Unraveling the impact of ORF3a Q57H mutation on SARS-CoV-2: insights from molecular dynamics

MJ Islam, MS Alom, MS Hossain, MA Ali… - Journal of …, 2024 - Taylor & Francis
ORF3a is a conserved accessory protein of SARS-CoV-2, linked to viral infection and
pathogenesis, with acquired mutations at various locations. Previous studies have shown …