Salivary glands produce and secrete saliva, which is essential for maintaining oral health
and overall health. Understanding both the unique structure and physiological function of …

Salivary glands are essential organs that produce and secrete saliva to the oral cavity.
During gland morphogenesis, many developmental processes involve a series of …

Understanding the dynamic transcriptional landscape throughout organ development will
provide a template for regenerative therapies. Here, we generated a single-cell RNA …

Salivary gland acinar cells are routinely destroyed during radiation treatment for head and
neck cancer that results in a lifetime of hyposalivation and co‐morbidities. A potential …

Salivary gland (SG) dysfunction, due to radiotherapy, disease, or aging, is a clinical
manifestation that has the potential to cause severe oral and/or systemic diseases and …

Acinar cells play an essential role in the secretory function of exocrine organs. Despite this
requirement, how acinar cells are generated during organogenesis is unclear. Using the …

Stem and progenitor cells of the submandibular salivary gland (SMG) give rise to, maintain,
and regenerate the multiple lineages of mature epithelial cells including those belonging to …

The epithelial-to-mesenchymal transition (EMT) transcriptional program is characterized by
repression of E-cadherin (CDH1) and induction of N-cadherin (CDH2), and mesenchymal …

The mechanisms that prevent regeneration of irradiated (IR) salivary glands remain elusive.
Bulk RNAseq of IR versus non-IR human salivary glands showed that neurotrophin …

Characterizing the complex composition of solid tumors is fundamental for understanding
tumor initiation, progression and metastasis. While patient-derived samples provide …