This paper introduces a new construct, the 'pivotal mental state', which is defined as a hyper-
plastic state aiding rapid and deep learning that can mediate psychological transformation …

Elevated whole blood serotonin, or hyperserotonemia, was the first biomarker identified in
autism spectrum disorder (ASD) and is present in more than 25% of affected children. The …

Humans and many other animals have an enormous capacity to learn about sensory stimuli
and to master new skills. However, many of the mechanisms that enable us to learn remain …

Serotonin (5-HT) shapes brain networks during development and modulates a wide
spectrum of essential neuronal functions ranging from perception and cognitive appraisal to …

Serotonin is implicated in mood and affective disorders. However, growing evidence
suggests that a core endogenous role is to promote flexible adaptation to changes in the …

Fifty years ago, increased whole-blood serotonin levels, or hyperserotonemia, first linked
disrupted 5-HT homeostasis to Autism Spectrum Disorders (ASDs). The 5-HT transporter …

Sensory experience is critical to development and plasticity of neural circuits. Here we report
a new form of plasticity in neonatal mice, where early sensory experience cross-modally …

The brain is programmed to drive behaviour by precisely wiring the appropriate neuronal
circuits. Wiring and rewiring of neuronal circuits largely depends on the orchestrated …

Learning induces plastic changes in synapses. However, the regulatory molecules that
orchestrate learning-induced synaptic changes are largely unknown. Although it is well …

Serotonin (5-HT) is associated with mood and motivation but the function of endogenous 5-
HT remains controversial. Here, we studied the impact of phasic optogenetic activation of 5 …