Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …

There are several interrelated mechanisms involving iron, dopamine, and neuromelanin in
neurons. Neuromelanin accumulates during aging and is the catecholamine-derived …

The molecular mechanisms causing the loss of dopaminergic neurons containing
neuromelanin in the substantia nigra and responsible for motor symptoms of Parkinson's …

Intrinsically disordered proteins (IDPs) play many biological roles in the human proteome
ranging from vesicular transport, signal transduction to neurodegenerative diseases. The Aβ …

Parkinson's disease (PD) is the second most common neurodegenerative disease. The
characteristic feature of PD is the progressive degeneration of the dopaminergic (DAergic) …

Parkinson's disease, the second most common neurodegenerative disorder worldwide, is
characterized by the accumulation of protein deposits in the dopaminergic neurons. These …

Parkinson's disease (PD) is characterized by an abnormal post-translational modifications
(PTM) in amino acid sequence and aggregation of alpha-synuclein (α-Syn) protein. It is …

Summary α-Synuclein plays an important role in synaptic functions by interacting with
synaptic vesicle membrane, while its oligomers and fibrils are associated with several …

A host of human diseases, including Parkinson's disease and Dementia with Lewy bodies,
are suspected to be directly linked to protein aggregation. Amyloid protein aggregates and …

The intrinsically disordered and amyloidogenic protein α-synuclein (AS) has been linked to
several neurodegenerative states, including Parkinson's disease. Here, nanoelectrospray …