▪ Abstract DNA damage is a relatively common event in the life of a cell and may lead to
mutation, cancer, and cellular or organismic death. Damage to DNA induces several cellular …

Aging is an intricate phenomenon characterized by progressive decline in physiological
functions and increase in mortality that is often accompanied by many pathological …

Microarrays can measure the expression of thousands of genes to identify changes in
expression between different biological states. Methods are needed to determine the …

Purpose Both temozolomide (TMZ) and poly (ADP-ribose) polymerase (PARP) inhibitors are
active in small-cell lung cancer (SCLC). This phase II, randomized, double-blind study …

Purpose: To evaluate the preclinical pharmacokinetics and antitumor efficacy of a novel
orally bioavailable poly (ADP-ribose) polymerase (PARP) inhibitor, ABT-888. Experimental …

Eukaryotic cells can repair many types of DNA damage. Among the known DNA repair
processes in humans, one type—nucleotide excision repair (NER)—specifically protects …

The genomic integrity of every organism is constantly challenged by endogenous and
exogenous DNA-damaging factors. Mutagenic agents cause reduced stability of plant …

Much is now known about the carcinogens in cigarette smoke, their conversion to forms that
react with DNA, and the miscoding properties of the resulting DNA adducts that cause the …

DNA damage is induced by many factors, some of which naturally occur in the environment.
Because of their sessile nature, plants are especially exposed to unfavorable conditions …

Selenium (Se) is an essential dietary component for animals including humans and is
regarded as a protective agent against cancer. Although the mode of anticancer action of Se …