Degeneration of the intervertebral discs, a process characterized by a cascade of cellular,
biochemical, structural and functional changes, is strongly implicated as a cause of low back …

BACKGROUND CONTEXT: Degeneration and injuries of the intervertebral disc (IVD) result
in large alterations in biomechanical behaviors. Repair strategies using biomaterials can be …

Intervertebral disc degeneration, which mimics disc aging but occurs at an accelerated rate,
is considered to be related to neck or low back pain and disc herniation. Degenerated discs …

Lumbar discectomy is a very effective therapy for neurological decompression in patients
suffering from sciatica due to hernia nuclei pulposus. However, high recurrence rates and …

BACKGROUND CONTEXT: Recent studies have demonstrated new therapeutic strategy
using transplantation of mesenchymal stem cells (MSCs), especially bone marrow–derived …

Study Design. To identify mesenchymal stromal cells (MSC) from degenerate human
nucleus pulposus (NP) and compare them with bone marrow (BM) MSC. Objective. To test …

Low back pain affects a large portion of the population, resulting in high care costs for
therapy and treatment. One primary cause of low back pain is the degeneration of the …

Study Design. Experimental and descriptive study of a xenotransplantation model in
minipigs. Objective. To study survival and function of human mesenchymal stem cells …

Degeneration of the intervertebral disc (IVD) represents a significant musculoskeletal
disease burden. Although spinal fusion has some efficacy in pain management, spine …

There is evidence that mesenchymal stem cells (MSCs) can differentiate towards an
intervertebral disc (IVD)-like phenotype. We compared the standard chondrogenic protocol …