[HTML][HTML] Cytoplasmic RNA decay pathways-Enzymes and mechanisms
RNA decay plays a crucial role in post-transcriptional regulation of gene expression. Work
conducted over the last decades has defined the major mRNA decay pathways, as well as …
conducted over the last decades has defined the major mRNA decay pathways, as well as …
RNA decay machines: Deadenylation by the Ccr4–Not and Pan2–Pan3 complexes
E Wahle, GS Winkler - Biochimica et Biophysica Acta (BBA)-Gene …, 2013 - Elsevier
Shortening and removal of the 3′ poly (A) tail of mature mRNA by poly (A)-specific 3′
exonucleases (deadenylases) is the initial and often rate-limiting step in mRNA degradation …
exonucleases (deadenylases) is the initial and often rate-limiting step in mRNA degradation …
[HTML][HTML] Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs
Here, we demonstrate that protein-coding RNA transcripts can crosstalk by competing for
common microRNAs, with microRNA response elements as the foundation of this …
common microRNAs, with microRNA response elements as the foundation of this …
mRNA deadenylation is coupled to translation rates by the differential activities of Ccr4-Not nucleases
Translation and decay of eukaryotic mRNAs is controlled by shortening of the poly (A) tail
and release of the poly (A)-binding protein Pab1/PABP. The Ccr4-Not complex contains two …
and release of the poly (A)-binding protein Pab1/PABP. The Ccr4-Not complex contains two …
Mixed tailing by TENT4A and TENT4B shields mRNA from rapid deadenylation
RNA tails play integral roles in the regulation of messenger RNA (mRNA) translation and
decay. Guanylation of the poly (A) tail was discovered recently, yet the enzymology and …
decay. Guanylation of the poly (A) tail was discovered recently, yet the enzymology and …
The Ccr4–not complex
The Ccr4–Not complex is a unique, essential and conserved multi-subunit complex that acts
at the level of many different cellular functions to regulate gene expression. Two enzymatic …
at the level of many different cellular functions to regulate gene expression. Two enzymatic …
CNOT 6L couples the selective degradation of maternal transcripts to meiotic cell cycle progression in mouse oocyte
QQ Sha, JL Yu, JX Guo, XX Dai, JC Jiang… - The EMBO …, 2018 - embopress.org
Meiotic resumption‐coupled degradation of maternal transcripts occurs during oocyte
maturation in the absence of mRNA transcription. The CCR 4–NOT complex has been …
maturation in the absence of mRNA transcription. The CCR 4–NOT complex has been …
Ccr4-Not complex: the control freak of eukaryotic cells
The purpose of this review is to provide an analysis of the latest developments on the
functions of the carbon catabolite-repression 4-Not (Ccr4-Not) complex in regulating …
functions of the carbon catabolite-repression 4-Not (Ccr4-Not) complex in regulating …
Cytidine-containing tails robustly enhance and prolong protein production of synthetic mRNA in cell and in vivo
Synthetic mRNAs are rising rapidly as alternative therapeutic agents for delivery of proteins.
However, the practical use of synthetic mRNAs has been restricted by their low cellular …
However, the practical use of synthetic mRNAs has been restricted by their low cellular …
Deadenylase-dependent mRNA decay of GDF15 and FGF21 orchestrates food intake and energy expenditure
S Katsumura, N Siddiqui, MR Goldsmith, JH Cheah… - Cell metabolism, 2022 - cell.com
Hepatokines, secretory proteins from the liver, mediate inter-organ communication to
maintain a metabolic balance between food intake and energy expenditure. However …
maintain a metabolic balance between food intake and energy expenditure. However …