Neurodegenerative diseases are characterised by progressive damage to the nervous
system including the selective loss of vulnerable populations of neurons leading to motor …

Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

Dysfunction of microglia is known to play an important role in Alzheimer's disease (AD).
Here, we investigated the role of RIPK1 in microglia mediating the pathogenesis of AD …

Glial fibrillary acidic protein (GFAP) is the main intermediate filament protein in mature
astrocytes, but also an important component of the cytoskeleton in astrocytes during …

Between the 1960s and 1980s, most life scientists focused their attention on studies of
nucleic acids and the translation of the coded information. Protein degradation was a …

Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by
synaptic dysfunction and accumulation of abnormal aggregates formed by amyloid‐β …

▪ Abstract The conjugation of ubiquitin to other cellular proteins regulates a broad range of
eukaryotic cell functions. The high efficiency and exquisite selectivity of ubiquitination …

Slowly but surely, Alzheimer's disease (AD) patients lose their memory and their cognitive
abilities, and even their personalities may change dramatically. These changes are due to …

Recently, we demonstrated a significant increase of an oxidized nucleoside derived from
RNA, 8-hydroxyguanosine (8OHG), and an oxidized amino acid, nitrotyrosine in vulnerable …

The discovery of the ubiquitin pathway and its many substrates and functions has
revolutionized our concept of intracellular protein degradation. From an unregulated, non …