A review of adropin as the medium of dialogue between energy regulation and immune regulation

S Zhang, Q Chen, X Lin, M Chen… - Oxidative medicine and …, 2020 - Wiley Online Library
Adropin is a secretory protein encoded by the energy balance gene and is closely
associated with regulation of energy metabolism and insulin resistance. The clinical findings …

Unveiling the multifaceted role of adropin in various diseases

L Chen, J Lu, J Hu, X Gong - … Journal of Molecular …, 2024 - spandidos-publications.com
Adropin is a secreted peptide encoded by the energy homeostasis-associated gene, which
also functions as a membrane-bound protein facilitating intercellular communication. This …

[HTML][HTML] Neurovascular protection by adropin in experimental ischemic stroke through an endothelial nitric oxide synthase-dependent mechanism

C Yang, BP Lavayen, L Liu, BD Sanz, KM DeMars… - Redox Biology, 2021 - Elsevier
Adropin is a highly-conserved peptide that has been shown to preserve endothelial barrier
function. Blood-brain barrier (BBB) disruption is a key pathological event in cerebral …

Low plasma adropin concentrations increase risks of weight gain and metabolic dysregulation in response to a high-sugar diet in male nonhuman primates

AA Butler, J Zhang, CA Price, JR Stevens… - Journal of Biological …, 2019 - ASBMB
Mouse studies linking adropin, a peptide hormone encoded by the energy homeostasis–
associated (ENHO) gene, to biological clocks and to glucose and lipid metabolism suggest a …

Therapeutic benefits of adropin in aged mice after transient ischemic stroke via reduction of blood-brain barrier damage

C Yang, L Liu, BP Lavayen, J Larochelle, RE Gunraj… - Stroke, 2023 - Am Heart Assoc
Background: Adropin is a peptide encoded by the energy homeostasis-associated gene
(Enho) that is highly expressed in the brain. Aging and stroke are associated with reduced …

Adropin correlates with aging-related neuropathology in humans and improves cognitive function in aging mice

S Banerjee, S Ghoshal, C Girardet… - npj Aging and …, 2021 - nature.com
The neural functions of adropin, a secreted peptide highly expressed in the brain, have not
been investigated. In humans, adropin is highly expressed in astrocytes and peaks during …

Role of adropin in cardiometabolic disorders: from pathophysiological mechanisms to therapeutic target

J Bozic, M Kumric, T Ticinovic Kurir, I Males… - Biomedicines, 2021 - mdpi.com
Although a large amount of data supports the crucial role of endothelial dysfunction (ED) in
cardiovascular diseases (CVDs), there is a large bench-to-bedside chasm between basic …

[HTML][HTML] Age-dependent changes in the medial prefrontal cortex and medial amygdala structure, and elevated plus-maze performance in the healthy male Wistar rats

N Sotoudeh, MR Namavar, A Zarifkar… - IBRO reports, 2020 - Elsevier
Aging affects different parts of the brain structure and function. These changes are
associated with several age-related emotional alterations like anxiety that is regulated by the …

[HTML][HTML] Adropin: A crucial regulator of cardiovascular health and metabolic balance

S Rooban, KAA Senghor, VM Vinodhini, JS Kumar - Metabolism Open, 2024 - Elsevier
Adropin, a peptide discovered in 2008, has gained recognition as a key regulator of
cardiovascular health and metabolic balance. Initially identified for its roles in energy …

Optimisation of ketamine‐xylazine anaesthetic dose and its association with changes in the dendritic spine of CA1 hippocampus in the young and old male and …

N Sotoudeh, MR Namavar - Veterinary Medicine and Science, 2022 - Wiley Online Library
Background A combination of ketamine‐xylazine (K‐X) is frequently used for anaesthesia in
rats. Sex and age affect this cocktail dosage. Ketamine causes a hypnotic effect by blocking …