Animal modeling has been instrumental in dissecting pathophysiological mechanisms and
designing more effective therapies in many areas of medicine but not so in psychiatry. The …

The contribution of extrinsic and genetic mechanisms in determining areas of the
mammalian neocortex has been a contested issue. This study analyzes the roles of the …

Transformed stem cells have been isolated from some human cancers. We report that,
unlike other brain cancers, the lethal glioblastoma multiforme contains neural precursors …

The availability of human pluripotent stem cells (hPSCs) offers the opportunity to generate
lineage-specific cells to investigate mechanisms of human diseases specific to brain …

Microglia are observed in the early develo** forebrain and contribute to the regulation of
neurogenesis through still unravelled mechanisms. In the develo** cerebral cortex …

ABSTRACT Bone Morphogenetic Proteins (BMPs) play crucial roles in a variety of
developmental processes, but their functions during early vertebrate brain development are …

The homeobox, a 60-amino acid-encoding DNA sequence, originally discovered in the
genome of the fruit fly Drosophila, was subsequently identified throughout the three …

Constitutive heterochromatin is traditionally viewed as the static form of heterochromatin that
silences pericentromeric and telomeric repeats in a cell cycle-and differentiation …

Hox genes have a well-characterized role in embryonic development, where they determine
identity along the anteroposterior body axis. Hox genes are expressed not only during …

Cranial placodes are specialized regions of the ectoderm, which give rise to various sensory
ganglia and contribute to the pituitary gland and sensory organs of the vertebrate head …