Inflammasomes are multiprotein signalling platforms that control the inflammatory response
and coordinate antimicrobial host defences. They are assembled by pattern-recognition …

Twelve regulated cell death programs have been described. We review in detail the basic
biology of nine including death receptor-mediated apoptosis, death receptor-mediated …

Inflammasomes are key signalling platforms that detect pathogenic microorganisms and
sterile stressors, and that activate the highly pro-inflammatory cytokines interleukin-1β (IL …

Caspases are a family of endoproteases that provide critical links in cell regulatory networks
controlling inflammation and cell death. The activation of these enzymes is tightly controlled …

Caspases are proteases with a well-defined role in apoptosis. However, increasing
evidence indicates multiple functions of caspases outside apoptosis. Caspase-1 and …

We present a DNA library preparation method that has allowed us to reconstruct a high-
coverage (30×) genome sequence of a Denisovan, an extinct relative of Neandertals. The …

The innate immune system relies on its capacity to rapidly detect invading pathogenic
microbes as foreign and to eliminate them. The discovery of Toll-like receptors (TLRs) …

Disturbances in the normal functions of the ER lead to an evolutionarily conserved cell
stress response, the unfolded protein response, which is aimed initially at compensating for …

Here we present a draft genome sequence of the common chimpanzee (Pan troglodytes).
Through comparison with the human genome, we have generated a largely complete …

IL-1β production is critically regulated by cytosolic molecular complexes, termed
inflammasomes. Different inflammasome complexes have been described to date. While all …