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The calcium-sensing receptor in health and disease
The extracellular calcium-sensing receptor (CaSR) is a unique G protein–coupled receptor
(GPCR) activated by extracellular Ca 2+ and by other physiological cations including Mg 2+ …
(GPCR) activated by extracellular Ca 2+ and by other physiological cations including Mg 2+ …
Calcium nutrition and extracellular calcium sensing: relevance for the pathogenesis of osteoporosis, cancer and cardiovascular diseases
Through a systematic search in Pubmed for literature, on links between calcium malnutrition
and risk of chronic diseases, we found the highest degree of evidence for osteoporosis …
and risk of chronic diseases, we found the highest degree of evidence for osteoporosis …
Enhanced Ca2+-Sensing Receptor Function in Idiopathic Pulmonary Arterial Hypertension
A Yamamura, Q Guo, H Yamamura… - Circulation …, 2012 - ahajournals.org
Rationale: A rise in cytosolic Ca2+ concentration ([Ca2+] cyt) in pulmonary arterial smooth
muscle cells (PASMC) is an important stimulus for pulmonary vasoconstriction and vascular …
muscle cells (PASMC) is an important stimulus for pulmonary vasoconstriction and vascular …
Cinacalcet-mediated activation of the CaMKKβ-LKB1-AMPK pathway attenuates diabetic nephropathy in db/db mice by modulation of apoptosis and autophagy
JH Lim, HW Kim, MY Kim, TW Kim, EN Kim, Y Kim… - Cell Death & …, 2018 - nature.com
Apoptosis and autophagy are harmoniously regulated biological processes for maintaining
tissue homeostasis. AMP-activated protein kinase (AMPK) functions as a metabolic sensor …
tissue homeostasis. AMP-activated protein kinase (AMPK) functions as a metabolic sensor …
The vascular Ca2+-sensing receptor regulates blood vessel tone and blood pressure
The extracellular calcium-sensing receptor CaSR is expressed in blood vessels where its
role is not completely understood. In this study, we tested the hypothesis that the CaSR …
role is not completely understood. In this study, we tested the hypothesis that the CaSR …
Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics
Background and Purpose Clinical use of cinacalcet in hyperparathyroidism is complicated
by its tendency to induce hypocalcaemia, arising partly from activation of calcium‐sensing …
by its tendency to induce hypocalcaemia, arising partly from activation of calcium‐sensing …
[HTML][HTML] The different facets of extracellular calcium sensors: old and new concepts in calcium-sensing receptor signalling and pharmacology
The current interest of the scientific community for research in the field of calcium sensing in
general and on the calcium-sensing Receptor (CaR) in particular is demonstrated by the still …
general and on the calcium-sensing Receptor (CaR) in particular is demonstrated by the still …
Important roles of the Ca2+-sensing receptor in vascular health and disease
Y Guo, X Yang, J He, J Liu, S Yang, H Dong - Life sciences, 2018 - Elsevier
Abstract Ca 2+-sensing receptor (CaSR), a member of G protein-coupled receptor family, is
widely expressed in the vascular system, including perivascular neurons, vascular …
widely expressed in the vascular system, including perivascular neurons, vascular …
[HTML][HTML] Heteromeric TRPV4/TRPC1 channels mediate calcium-sensing receptor-induced nitric oxide production and vasorelaxation in rabbit mesenteric arteries
HZE Greenberg, SRE Carlton-Carew, DM Khan… - Vascular …, 2017 - Elsevier
Stimulation of calcium-sensing receptors (CaSR) by increasing the external calcium
concentration (Ca 2+] o) induces endothelium-dependent vasorelaxation through nitric …
concentration (Ca 2+] o) induces endothelium-dependent vasorelaxation through nitric …
Coronary artery calcification in chronic kidney disease: An update
Arterial calcification is a well-recognized complication of advanced atherosclerosis. Chronic
kidney disease (CKD) is characterized by significantly more pronounced, disseminated and …
kidney disease (CKD) is characterized by significantly more pronounced, disseminated and …