Strategies to address low drug solubility in discovery and development

HD Williams, NL Trevaskis, SA Charman… - Pharmacological …, 2013 - Elsevier
Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …

Micellar nanocarriers: pharmaceutical perspectives

VP Torchilin - Pharmaceutical research, 2007 - Springer
Micelles, self-assembling nanosized colloidal particles with a hydrophobic core and
hydrophilic shell are currently successfully used as pharmaceutical carriers for water …

[BOOK][B] Food emulsions: principles, practices, and techniques

DJ McClements - 2004 - taylorfrancis.com
Food Emulsions: Principles, Practice, and Techniques, Second Edition introduces the
fundamentals of emulsion science and demonstrates how this knowledge can be applied to …

Structure and design of polymeric surfactant-based drug delivery systems

VP Torchilin - Journal of controlled release, 2001 - Elsevier
The review concentrates on the use of polymeric micelles as pharmaceutical carriers.
Micellization of biologically active substances is a general phenomenon that increases the …

Solubilization of membranes by detergents

A Helenius, KAI Simons - Biochimica et Biophysica Acta (BBA)-Reviews on …, 1975 - Elsevier
30 membrane structure and function it is usually necessary to dissociate the membrane into
its components. The techniques for extraction and analysis of the membrane lipids are well …

[BOOK][B] Catalysis in micellar and macromoleular systems

J Fendler - 2012 - books.google.com
Catalysis in Micellar and Macromolecular Systems provides a comprehensive monograph
on the catalyses elicited by aqueous and nonaqueous micelles, synthetic and naturally …

Water solubility enhancement of some organic pollutants and pesticides by dissolved humic and fulvic acids

CT Chiou, RL Malcolm, TI Brinton… - Environmental science & …, 1986 - ACS Publications
Water solubility enhancements by dissolved humic and fulvic acids from soil and aquatic
origins and by synthetic organic polymers have been determined for selected or-ganic …

Theory of surfactant self-assembly: a predictive molecular thermodynamic approach

R Nagarajan, E Ruckenstein - Langmuir, 1991 - ACS Publications
A thermodynamic treatment of surfactant self-assembly in aqueous media is developed that
allows an a priori quantitative prediction of the aggregation behavior of surfactants, starting …

A century of dissolution research: from Noyes and Whitney to the biopharmaceutics classification system

A Dokoumetzidis, P Macheras - International journal of pharmaceutics, 2006 - Elsevier
Dissolution research started to develop about 100 years ago as a field of physical chemistry
and since then important progress has been made. However, explicit interest in drug related …

[BOOK][B] Handbook of surface and colloid chemistry

KS Birdi - 2008 - taylorfrancis.com
The third edition of this besteller covers the latest advancements in this rapidly growing field.
Focusing on analyses and critical evaluation of the subject, this new edition reviews the …