Pyroptosis is a form of regulated cell death that is mediated by the membrane-targeting, pore-
forming gasdermin family of proteins. Pyroptosis was initially described as a caspase 1-and …

Single-cell sequencing, including genomics, transcriptomics, epigenomics, proteomics and
metabolomics sequencing, is a powerful tool to decipher the cellular and molecular …

Abstract CellMarker 2.0 (http://bio-bigdata. hrbmu. edu. cn/CellMarker or http://117.50.
127.228/CellMarker/) is an updated database that provides a manually curated collection of …

Cell–cell interactions orchestrate organismal development, homeostasis and single-cell
functions. When cells do not properly interact or improperly decode molecular messages …

Understanding gene function and regulation in homeostasis and disease requires
knowledge of the cellular and tissue contexts in which genes are expressed. Here, we …

Histone lysine crotonylation (Kcr), as a posttranslational modification, is widespread as
acetylation (Kac); however, its roles are largely unknown in kidney fibrosis. In this study, we …

Organoids serve as a novel tool for disease modeling in three-dimensional multicellular
contexts. Static organoids, however, lack the requisite biophysical microenvironment such …

Chronic kidney disease (CKD) is the leading complication in type 2 diabetes (T2D) and
current therapies that limit CKD progression and the development of cardiovascular disease …

After acute kidney injury (AKI), patients either recover or alternatively develop fibrosis and
chronic kidney disease. Interactions between injured epithelia, stroma, and inflammatory …

Background Single-cell RNA sequencing has been widely adopted to estimate the cellular
composition of heterogeneous tissues and obtain transcriptional profiles of individual cells …