Facing and overcoming sensitivity challenges in biomolecular NMR spectroscopy
In the Spring of 2013, NMR spectroscopists convened at the Weizmann Institute in Israel to
brainstorm on approaches to improve the sensitivity of NMR experiments, particularly when …
brainstorm on approaches to improve the sensitivity of NMR experiments, particularly when …
Tumor imaging using hyperpolarized 13C magnetic resonance spectroscopy
Dynamic nuclear polarization is an emerging technique for increasing the sensitivity of
magnetic resonance imaging and spectroscopy, particularly for low‐γ nuclei. The technique …
magnetic resonance imaging and spectroscopy, particularly for low‐γ nuclei. The technique …
[HTML][HTML] Deuterium metabolic imaging in the human brain at 9.4 Tesla with high spatial and temporal resolution
Purpose To present first highly spatially resolved deuterium metabolic imaging (DMI)
measurements of the human brain acquired with a dedicated coil design and a fast chemical …
measurements of the human brain acquired with a dedicated coil design and a fast chemical …
Accelerated MR spectroscopic imaging—a review of current and emerging techniques
Over more than 30 years in vivo MR spectroscopic imaging (MRSI) has undergone an
enormous evolution from theoretical concepts in the early 1980s to the robust imaging …
enormous evolution from theoretical concepts in the early 1980s to the robust imaging …
Hyperpolarized magnetic resonance as a sensitive detector of metabolic function
Hyperpolarized magnetic resonance allows for noninvasive measurements of biochemical
reactions in vivo. Although this technique provides a unique tool for assaying enzymatic …
reactions in vivo. Although this technique provides a unique tool for assaying enzymatic …
Fast dynamic 3D MR spectroscopic imaging with compressed sensing and multiband excitation pulses for hyperpolarized 13C studies
Hyperpolarized 13C MR spectroscopic imaging can detect not only the uptake of the pre‐
polarized molecule but also its metabolic products in vivo, thus providing a powerful new …
polarized molecule but also its metabolic products in vivo, thus providing a powerful new …
Hyperpolarized 13C dehydroascorbate as an endogenous redox sensor for in vivo metabolic imaging
Reduction and oxidation (redox) chemistry is involved in both normal and abnormal cellular
function, in processes as diverse as circadian rhythms and neurotransmission. Intracellular …
function, in processes as diverse as circadian rhythms and neurotransmission. Intracellular …
A hyperpolarized equilibrium for magnetic resonance
Nuclear magnetic resonance spectroscopy and imaging (MRI) play an indispensable role in
science and healthcare but use only a tiny fraction of their potential. No more than≈ 10 ppm …
science and healthcare but use only a tiny fraction of their potential. No more than≈ 10 ppm …
3D compressed sensing for highly accelerated hyperpolarized 13C MRSI with in vivo applications to transgenic mouse models of cancer
S Hu, M Lustig, A Balakrishnan… - … in Medicine: An …, 2010 - Wiley Online Library
High polarization of nuclear spins in liquid state through hyperpolarized technology utilizing
dynamic nuclear polarization has enabled the direct monitoring of 13C metabolites in vivo at …
dynamic nuclear polarization has enabled the direct monitoring of 13C metabolites in vivo at …
Hyperpolarized 13C metabolic imaging using dissolution dynamic nuclear polarization
This article describes the basic physics of dissolution dynamic nuclear polarization
(dissolution‐DNP), and the impact of the resulting highly nonequilibrium spin states, on the …
(dissolution‐DNP), and the impact of the resulting highly nonequilibrium spin states, on the …