A higher incidence of colorectal cancer (CRC) is found in males compared to females.
Young women (18–44 years) with CRC have a better survival outcome compared to men of …

There is an unmet need in severe asthma where approximately 40% of patients exhibit poor
β-agonist responsiveness, suffer daily symptoms and show frequent exacerbations …

The large conductance, voltage-and calcium-dependent potassium BK channel, also termed
BK Ca, Maxi-K, K Ca 1.1, or SLO1, regulates a wide array of key biological processes that …

The processes regulating glucose-stimulated insulin secretion (GSIS) and its modulation by
incretins in pancreatic β-cells are only partly understood. Here we investigate the …

Aim: Galectin-3 (Gal-3) is a member of the carbohydrate-binding protein family that
contributes to neoplastic transformation, tumor survival, angiogenesis, and metastasis. The …

Glycogen synthase kinase 3 (GSK3) is a serine/threonine kinase that has been implicated in
psychiatric diseases, neurodevelopment, and circadian regulation. Both GSK3 isoforms, α …

Pancreatic β-cells are highly responsive to changes in glucose, but the mechanisms
involved are only partially understood. There is increasing evidence that the β-catenin …

The accessory β1 subunit modulates the Ca2+-and voltage-activated K+ (BK) channel
gating properties mainly by increasing its apparent Ca2+ sensitivity. β1 plays an important …

It has been suggested that drug tolerance represents a form of learning and memory, but this
has not been experimentally established at the molecular level. We show that a component …

In breast cancers, the large conductance Ca2+ and voltage sensitive K+(BKCa) channels
have been hypothesized to function as oncoproteins, yet it remains unclear how inhibition of …