Recent progress in chemosensors based on pyrazole derivatives

A Tigreros, J Portilla - RSC advances, 2020 - pubs.rsc.org
Colorimetric and fluorescent probes based on small organic molecules have become
important tools in modern biology because they provide dynamic information concerning the …

Pyrazole Scaffolds: centrality in anti-inflammatory and antiviral drug design

D Karati, KR Mahadik, D Kumar - Medicinal Chemistry, 2022 - benthamdirect.com
Background: Pyrazole is a component of a diversity of bioactive heterocyclic congeners with
a broad-spectrum range of biological and pharmacological uses. Designing novel pyrazole …

Synthesis of new magnetic nanocatalyst Fe3O4@CPTMO-phenylalanine-Ni and its catalytic effect in the preparation of substituted pyrazoles

S Bikas, A Poursattar Marjani, S Bibak… - Scientific Reports, 2023 - nature.com
In this study, a new, efficient and stable magnetically heterogeneous nanocatalyst of
Fe3O4@ CPTMO-phenylalanine-Ni via multi steps process starting from simple and cost …

Electrochemical synthesis of pyrazolines and pyrazoles via [3+ 2] dipolar cycloaddition

M Linden, S Hofmann, A Herman… - Angewandte Chemie …, 2023 - Wiley Online Library
Pyrazolines and pyrazoles are common and important motifs of pharmaceutical agents and
agrochemicals. Herein, the first electrochemical approach for their direct synthesis from …

Development of novel bosentan analogues as endothelin receptor antagonists for pulmonary arterial hypertension

J Panchal, S Jaiswal, S Jain, J Kumawat… - European Journal of …, 2023 - Elsevier
Since decades, bosentan has been in use for the treatment of pulmonary arterial
hypertension (PAH). However, chronic exposure to bosentan leads to the development of …

Synthesis, biological screening and in silico studies of new N-phenyl-4-(1, 3-diaryl-1H-pyrazol-4-yl) thiazol-2-amine derivatives as potential antifungal and …

Y Nandurkar, MR Bhoye, D Maliwal… - European Journal of …, 2023 - Elsevier
A new series of N-aryl-4-(1, 3-diaryl-1H-pyrazol-4-yl) thiazol-2-amine,(8a-x) have been
synthesized by a cyclo-condensation reaction of 2-bromo-1-(1, 3-diphenyl-1H-pyrazol-4-yl) …

Experimental and theoretical tests on the corrosion protection of mild steel in hydrochloric acid environment by the use of pyrazole derivative

M Boudalia, RM Fernández-Domene, L Guo, S Echihi… - Materials, 2023 - mdpi.com
In this study, 1, 5-diallyl-1H-pyrazolo [3, 4-d] pyrimidin-4 (5H)-one (PPD) was evaluated as
an anticorrosion agent for mild steel (MS) in 1 M HCl. The analysis was performed by weight …

Applications of oxone® in organic synthesis: an emerging green reagent of modern era

S Alvi, V Jayant, R Ali - ChemistrySelect, 2022 - Wiley Online Library
Presently, the major cornerstone of the research community is to develop green as well as
sustainable protocols involving inexpensive catalysts and/or reagents without the usage of …

Berotralstat (BCX7353): structure-guided design of a potent, selective, and oral plasma kallikrein inhibitor to prevent attacks of hereditary angioedema (HAE)

PL Kotian, M Wu, S Vadlakonda… - Journal of Medicinal …, 2021 - ACS Publications
Hereditary angioedema (HAE) is a rare and potentially life-threatening disease that affects
an estimated 1 in 50 000 individuals worldwide. Until recently, prophylactic HAE treatment …

Synthesis of 1, 3, 5-trisubstituted pyrazoles via 1, 3-dipolar cycloaddition of nitrile imines with ninhydrin-derived Morita–Baylis–Hillman carbonates

KK Wang, YL Li, J **g, R Chen, NN Zhao… - Organic & …, 2022 - pubs.rsc.org
An effective synthetic method for 1, 3, 5-trisubstituted pyrazoles via 1, 3-dipolar cycloaddition
reaction has been developed. This reaction could smoothly proceed between ninhydrin …