The peak age of onset for many psychiatric disorders is adolescence, a time of remarkable
physical and behavioural changes. The processes in the brain that underlie these …

The goal of this review is to present a comprehensive survey of the many intriguing facets of
creatine (Cr) and creatinine metabolism, encompassing the pathways and regulation of Cr …

Background The pathophysiological characteristics of schizophrenia appear to involve
altered synaptic connectivity in the dorsolateral prefrontal cortex. Given the central role that …

The assembly of functional neural circuits requires the combined action of progressive and
regressive events. Regressive events encompass a variety of inhibitory developmental …

Major psychiatric illnesses such as mood disorders and schizophrenia are chronic, recurrent
mental illnesses that affect the lives of millions of individuals. Although these disorders have …

This article reviews the disconnection hypothesis of schizophrenia and presents a
mechanistic account of how dysfunctional integration among neuronal systems might arise …

Schizophrenia is commonly considered a neurodevelopmental disorder that is associated
with significant morbidity; however, unlike other neurodevelopmental disorders, the …

Schizophrenia is a disease in which morphologic abnor-malities have proven to be both
subtle and elusive. Indeed, the most notable observation is the normal appearance of the …

Bipolar disorder (BPD) and schizophrenia (SZ) are severe psychiatric illnesses with a
combined prevalence of 4%. A disturbance of energy metabolism is frequently observed in …

Schizophrenia is a major psychiatric disease, which affects the centre of the personality, with
severe problems of perception, cognition as well as affective and social behaviour. In …