The past two decades have witnessed the emergence of macrocycles, including macrocyclic
peptides, as a promising yet underexploited class of de novo drug candidates. Both …

Bicyclic peptides have greater conformational rigidity and metabolic stability than linear and
monocyclic peptides and are capable of binding to challenging drug targets with antibody …

Successful screening campaigns depend on large and structurally diverse collections of
compounds. In macrocycle screening, variation of the molecular scaffold is important for …

Genetic code expansion (GCE) offers many exciting opportunities for the creation of
synthetic organisms and for drug discovery methods that utilize in vitro translation. One type …

mRNA display is a powerful biological display platform for the directed evolution of proteins
and peptides. mRNA display libraries covalently link the displayed peptide or protein …

Macrocyclic peptides are promising scaffolds for the covalent ligand discovery. However,
platforms enabling the direct identification of covalent macrocyclic ligands in a high …

mRNA display is a robust in vitro selection technique that allows the selection of peptides
and proteins with desired functions from libraries of trillions of variants. mRNA display relies …

Macrocyclic peptides are a promising class of compounds that can often engage
challenging therapeutic targets. Display technologies, such as mRNA display, allow for the …

There is a demand for site-selective peptide/protein conjugation chemistry that is fully
reversible in a stimulus-responsive manner. The contemporary methods for site-selective …

The Zika virus presents a major public health concern due to severe fetal neurological
disorders associated with infections in pregnant women. In addition to vaccine development …