Critical reanalysis of the mechanisms underlying the cardiorenal benefits of SGLT2 inhibitors and reaffirmation of the nutrient deprivation signaling/autophagy …
SGLT2 (sodium-glucose cotransporter 2) inhibitors produce a distinctive pattern of benefits
on the evolution and progression of cardiomyopathy and nephropathy, which is …
on the evolution and progression of cardiomyopathy and nephropathy, which is …
Cardiac energy metabolism in heart failure
Alterations in cardiac energy metabolism contribute to the severity of heart failure. However,
the energy metabolic changes that occur in heart failure are complex and are dependent not …
the energy metabolic changes that occur in heart failure are complex and are dependent not …
Empagliflozin in acute myocardial infarction: the EMMY trial
D von Lewinski, E Kolesnik, NJ Tripolt… - European heart …, 2022 - academic.oup.com
Aims Sodium–glucose co-transporter 2 inhibition reduces the risk of hospitalization for heart
failure and for death in patients with symptomatic heart failure. However, trials investigating …
failure and for death in patients with symptomatic heart failure. However, trials investigating …
SGLT2 inhibitors: role in protective reprogramming of cardiac nutrient transport and metabolism
Abstract Sodium–glucose cotransporter 2 (SGLT2) inhibitors reduce heart failure events by
direct action on the failing heart that is independent of changes in renal tubular function. In …
direct action on the failing heart that is independent of changes in renal tubular function. In …
Signaling pathways in obesity: mechanisms and therapeutic interventions
Obesity is a complex, chronic disease and global public health challenge. Characterized by
excessive fat accumulation in the body, obesity sharply increases the risk of several …
excessive fat accumulation in the body, obesity sharply increases the risk of several …
Hallmarks of cardiovascular ageing
Normal circulatory function is a key determinant of disease-free life expectancy (healthspan).
Indeed, pathologies affecting the cardiovascular system, which are growing in prevalence …
Indeed, pathologies affecting the cardiovascular system, which are growing in prevalence …
Molecular mechanisms of ferroptosis and relevance to inflammation
L Deng, S He, N Guo, W Tian, W Zhang, L Luo - Inflammation Research, 2023 - Springer
Introduction Inflammation is a defensive response of the organism to irritation which is
manifested by redness, swelling, heat, pain and dysfunction. The inflammatory response …
manifested by redness, swelling, heat, pain and dysfunction. The inflammatory response …
Astrocytic LRP1 enables mitochondria transfer to neurons and mitigates brain ischemic stroke by suppressing ARF1 lactylation
J Zhou, L Zhang, J Peng, X Zhang, F Zhang, Y Wu… - Cell metabolism, 2024 - cell.com
Low-density lipoprotein receptor-related protein-1 (LRP1) is an endocytic/signaling cell-
surface receptor that regulates diverse cellular functions, including cell survival …
surface receptor that regulates diverse cellular functions, including cell survival …
Metabolic mechanisms in physiological and pathological cardiac hypertrophy: new paradigms and challenges
Cardiac metabolism is vital for heart function. Given that cardiac contraction requires a
continuous supply of ATP in large quantities, the role of fuel metabolism in the heart has …
continuous supply of ATP in large quantities, the role of fuel metabolism in the heart has …
Sarcopenia and cardiovascular diseases: a systematic review and meta‐analysis
X Zuo, X Li, K Tang, R Zhao, M Wu… - Journal of Cachexia …, 2023 - Wiley Online Library
Sarcopenia is an age‐related disease and is often accompanied by other diseases. Now,
many studies have shown that cardiovascular diseases (CVDs) may raise the incidence rate …
many studies have shown that cardiovascular diseases (CVDs) may raise the incidence rate …