The blood-brain barrier (BBB) is a highly specialized brain endothelial structure of the fully
differentiated neurovascular system. In concert with pericytes, astrocytes, and microglia, the …

Alzheimer disease (AD) is biologically defined by the presence of β-amyloid-containing
plaques and tau-containing neurofibrillary tangles. AD is a genetic and sporadic …

Background Although statins reduce coronary and cerebrovascular morbidity and mortality
in middle-aged individuals, their efficacy and safety in elderly people is not fully established …

Background In cross-sectional studies, elevated plasma homocysteine levels have been
associated with poor cognition and dementia. Studies of newly diagnosed dementia are …

Objective: To determine the influence of type 2 diabetes mellitus on the risk of dementia and
AD. Background: Both dementia and diabetes are frequent disorders in elderly people …

Background Silent brain infarcts are frequently seen on magnetic resonance imaging (MRI)
in healthy elderly people and may be associated with dementia and cognitive decline …

▪ Abstract Statins are potent inhibitors of cholesterol biosynthesis. In clinical trials, statins are
beneficial in the primary and secondary prevention of coronary heart disease. However, the …

Objective: To examine the relation of midlife raised blood pressure and serum cholesterol
concentrations to Alzheimer's disease in later life. Design: Prospective, population based …

Background This is an update of our previous 2013 review. Several recent trials and
systematic reviews of the impact of exercise on people with dementia are reporting …

Cerebrovascular disease is the second most common cause of acquired cognitive
impairment and dementia and contributes to cognitive decline in the neurodegenerative …