Document Reviewers: Luis Alcocer (Mexico), Christina Antza (Greece), Mustafa Arici
(Turkey), Eduardo Barbosa (Brazil), Adel Berbari (Lebanon), Luıs Bronze (Portugal), John …

Importance An estimated 40% of dementia is potentially preventable by modifying 12 risk
factors throughout the life course. However, robust evidence for most of these risk factors is …

Vascular risk factors such as chronic hypertension are well-established major modifiable
factors for the development of cerebral small vessel disease (cSVD). In the present study …

The heart is a functional syncytium controlled by a delicate and sophisticated balance
ensured by the tight coordination of its several cell subpopulations. Accordingly …

Abstract Luis Alcocer (Mexico), Christina Antza (Greece), Mustafa Arici (Turkey), Eduardo
Barbosa (Brazil), Adel Berbari (Lebanon), Luís Bronze (Portugal), John Chalmers …

Abstract Background The triglyceride-glucose (TyG) index is a reliable surrogate marker of
insulin resistance and is associated with major adverse cardiovascular events (MACEs) in …

Background The quantitative relationship of incident cardiovascular disease (CVD) to
lifetime cumulative risk factor exposure is not well understood. Objectives Using CARDIA …

Summary Background In China, dementia poses a significant public health challenge,
exacerbated by an ageing population and lifestyle changes. This study assesses the …

Importance It remains unclear whether cystatin C and cystatin C–based kidney function
measures are associated with frailty trajectories and physical function decline. Objective To …

Background: The potential benefits or harms of intensive systolic blood pressure (BP) control
on cognitive function and cerebral blood flow in individuals with low diastolic blood pressure …