The ability of IL-2 to expand T cells with maintenance of functional activity has been
translated into the first reproducible effective human cancer immunotherapies. The …

The existence of interleukin (IL)-2 has been recognized for over 25 years, and it remains one
of the most extensively studied cytokines. Here we present a broad overview of IL-2 history …

Interleukin 1 (IL-1) is a protein with several biological activities regulating host defense and
immune responses. We report here the isolation of human IL-1 cDNA. It encodes a precursor …

Noncoding sequences have been tabulated for 211 messenger R'JAs from higher
eukaryotic cells. The 5′-proximal AUG triplet serves as the initiator codon in 95% of the …

From the increasing number of reports of eukaryotic polypeptide synthesisin E. coli it is clear
that the mode ofexpression affects not only the efficiency ofproduction, but the nature of the …

The continuously proliferating clones L/B AgA2, CB/Bm 7, Ba/C1, and Bc/Bm 11 were
established from bone marrow of MRL/LPR, CBA/J, and BALB/c mice. These clones carry …

Understanding binding properties at protein–protein interfaces has been limited to structural
and mutational analyses of natural binding partners or small peptides identified by phage …

The development of the T-and natural killer (NK) cell growth factor IL-2 has been a sentinel
force ushering in the era of immunotherapy in cancer. With the advent of clinical grade …

Mouse cell lines of different lineages have been established which constitutively secrete
large quantities of recombinant mouse interleukins (mIL2, mIL3, mIL4 or mIL5). An existing …

Abstract Human interleukin-2 (IL-2) is a glycoprotein of relative molecular mass (M r) 15,000,
which is released by T lymphocytes on stimulation with antigen or mitogen and functions as …