Emerging evidence highlights moderate hypoxia as a candidate treatment for brain
disorders. This systematic review examines findings and the methodological quality of …

Oxygen is essential for human life, yet a growing body of preclinical research is
demonstrating that chronic continuous hypoxia can be beneficial in models of mitochondrial …

Aging is a complex biological process characterized by the gradual decline of cellular
functions, increased susceptibility to diseases, and impaired stress responses. Hypoxia …

DNA repair deficiency can lead to segmental phenotypes in humans and mice, in which
certain tissues lose homeostasis while others remain seemingly unaffected. This may be …

Healthy lifestyles, such as those that include regular physical activity and a balanced diet,
are a powerful means to prevent chronic disease and age-related functional decline. A …

The human lifespan is influenced by various factors, with physical activity being a significant
contributor. Despite the clear benefit of exercise on health and longevity, the association …

Health is strongly affected by aging and lifespan-modulating interventions, but the molecular
mechanisms of mortality regulation remain unclear. Here, we conducted an RNA-seq …

In this study, theories of aging and its mechanisms under various environmental conditions
were analyzed. The analysis of published data suggested that aging is a controlled process …

Nicotinamide adenine dinucleotide (NAD) is an essential regulator of cellular metabolism
and redox processes. NAD levels and the dynamics of NAD metabolism change with …

The animal gut microbiome acts as a crucial link between the host and its environment,
playing a vital role in digestion, metabolism, physiology, and fitness. Using 16S rRNA …