Detrusor underactivity and the underactive bladder: Symptoms, function, cause—what do we mean? ICI‐RS think tank 2014

PP Smith, LA Birder, P Abrams, AJ Wein… - Neurourology and …, 2016 - Wiley Online Library
Impaired bladder emptying is a well‐recognized cause of lower urinary tract symptoms.
However, the symptoms produced do not always relate to voiding, and may include …

Topical neurological stimulation

GH Creasey, H Toong - US Patent 10,016,600, 2018 - Google Patents
(57) ABSTRACT A topical nerve stimulator patch and system are provided comprising a
dermal patch; an electrical signal generator associated with the patch; a signal receiver to …

Electrical propagation in the renal pelvis, ureter and bladder

FT Hammad - Acta Physiologica, 2015 - Wiley Online Library
Under normal conditions, following the passage of urine from the collecting duct, the urine is
stored briefly in the renal pelvis before being transported through the ureter to the bladder …

Topical neurological stimulation

GH Creasey, H Toong - US Patent 10,307,591, 2019 - Google Patents
(57) ABSTRACT A topical nerve stimulator patch and system are provided comprising a
dermal patch; an electrical signal generator associated with the patch; a signal receiver to …

Impairment of ATP hydrolysis decreases adenosine A1 receptor tonus favoring cholinergic nerve hyperactivity in the obstructed human urinary bladder

M Silva-Ramos, I Silva, M Faria… - Purinergic …, 2015 - Springer
This study was designed to investigate whether reduced adenosine formation linked to
deficits in extracellular ATP hydrolysis by NTPDases contributes to detrusor …

Topical nerve stimulator and sensor for bladder control

G Creasey, HD Toong - US Patent 11,077,301, 2021 - Google Patents
What is provided is a method and apparatus for modifying bladder function comprising:
applying a dermal patch hav ing an integral electrode in proximity to a sacral or pudendal …

Age-dependent contribution of Rho kinase in carbachol-induced contraction of human detrusor smooth muscle in vitro

T Kirschstein, C Protzel, K Porath, T Sellmann… - Acta Pharmacologica …, 2014 - nature.com
Aim: Activation of muscarinic receptors on the detrusor smooth muscle is followed by
contraction, which involves both myosin light chain kinase (MLCK) and Rho kinase (ROCK) …

Topical neurological stimulation

GH Creasey, DT Hoo-min - US Patent 10,918,853, 2021 - Google Patents
(57) ABSTRACT A topical nerve stimulator patch and system are provided comprising a
dermal patch; an electrical signal generator associated with the patch; a signal receiver to …

Changes in nerve‐mediated contractility of the lower urinary tract in a mouse model of premature ageing

D Triguero, A Lafuente‐Sanchis… - British journal of …, 2014 - Wiley Online Library
Background and Purpose A high incidence of lower urinary tract disorders is associated with
ageing. In the senescent‐accelerated prone (SAMP8) mouse strain and the senescent …

Neuro activator with controller

T Spurling, A Wei, MB Druke, DT Hoo-min - US Patent 11,229,789, 2022 - Google Patents
(57) ABSTRACT A neuro activation system includes a patch adapted to be applied
externally on a dermis of a user, the patch compris ing a flexible substrate and an adhesive …