Antifungal therapy: new advances in the understanding and treatment of mycosis

L Scorzoni, ACA de Paula e Silva, CM Marcos… - Frontiers in …, 2017 - frontiersin.org
The high rates of morbidity and mortality caused by fungal infections are associated with the
current limited antifungal arsenal and the high toxicity of the compounds. Additionally …

Oxidative Stress Responses in the Human Fungal Pathogen, Candida albicans

A da Silva Dantas, A Day, M Ikeh, I Kos, B Achan… - Biomolecules, 2015 - mdpi.com
Candida albicans is a major fungal pathogen of humans, causing approximately 400,000 life-
threatening systemic infections world-wide each year in severely immunocompromised …

Enterococcus faecalis bacteriocin EntV inhibits hyphal morphogenesis, biofilm formation, and virulence of Candida albicans

CE Graham, MR Cruz, DA Garsin… - Proceedings of the …, 2017 - National Acad Sciences
Enterococcus faecalis, a Gram-positive bacterium, and Candida albicans, a fungus, occupy
overlap** niches as ubiquitous constituents of the gastrointestinal and oral microbiome …

Zebrafish as an alternative animal model in human and animal vaccination research

RL Bailone, HCS Fukushima… - Laboratory animal …, 2020 - Springer
Much of medical research relies on animal models to deepen knowledge of the causes of
animal and human diseases, as well as to enable the development of innovative therapies …

Two unlike cousins: Candida albicans and C. glabrata infection strategies

S Brunke, B Hube - Cellular microbiology, 2013 - Wiley Online Library
C andida albicans and C. glabrata are the two most common pathogenic yeasts of humans,
yet they are phylogenetically, genetically and phenotypically very different. In this review, we …

Infection of zebrafish embryos with intracellular bacterial pathogens

EL Benard, AM van der Sar, F Ellett… - Journal of …, 2012 - pmc.ncbi.nlm.nih.gov
Zebrafish (Danio rerio) embryos are increasingly used as a model for studying the function
of the vertebrate innate immune system in host-pathogen interactions 1. The major cell types …

Candidalysin activates innate epithelial immune responses via epidermal growth factor receptor

J Ho, X Yang, SA Nikou, N Kichik, A Donkin… - Nature …, 2019 - nature.com
Candida albicans is a fungal pathobiont, able to cause epithelial cell damage and immune
activation. These functions have been attributed to its secreted toxin, candidalysin, though …

A bacterial endosymbiont of the fungus Rhizopus microsporus drives phagocyte evasion and opportunistic virulence

H Itabangi, PCS Sephton-Clark, DP Tamayo, X Zhou… - Current biology, 2022 - cell.com
Opportunistic infections by environmental fungi are a growing clinical problem, driven by an
increasing population of people with immunocompromising conditions. Spores of the …

Emerging fungal pathogen Candida auris evades neutrophil attack

CJ Johnson, JM Davis, A Huttenlocher, JF Kernien… - MBio, 2018 - Am Soc Microbiol
Candida auris has recently emerged as the first fungal pathogen to cause a global public
health threat. The reason this species is causing hospital-associated outbreaks of invasive …

The Macrophage-Specific Promoter mfap4 Allows Live, Long-Term Analysis of Macrophage Behavior during Mycobacterial Infection in Zebrafish

EM Walton, MR Cronan, RW Beerman, DM Tobin - PloS one, 2015 - journals.plos.org
Transgenic labeling of innate immune cell lineages within the larval zebrafish allows for real-
time, in vivo analyses of microbial pathogenesis within a vertebrate host. To date, labeling of …