This review article describes the use of immune cells as potential candidates to deliver anti-
cancer drugs deep within the tumor microenvironment. First, the rationale of using drug …

Micromotors are devices that operate at the microscale and convert energy to motion. Many
micromotors are microswimmers, ie, devices that can move freely in a liquid at a low …

The targeting drug delivery systems (TDDS) have attracted extensive attention of
researchers in recent years. More and more drug/gene targeted delivery carriers, such as …

Oncolytic viruses capable of tumor-selective replication and cytolysis have shown early
promise as cancer therapeutics. However, the host immune system remains a significant …

Recent evidence suggests that mesenchymal stem cells (MSC) selectively proliferate to
tumors and contribute to the formation of tumor-associated stroma. The biological rationale …

The poor prognosis for patients with advanced malignancy relates partly to the inability to
reverse cancer metastasis. In this study we have investigated an integrated immunotherapy …

Oncolytic viruses delivered directly into the circulation face many hazards that impede their
localization to, and infection of, metastatic tumors. Such barriers to systemic delivery could …

Purpose: The purpose of the present study was to investigate whether it is possible to
achieve truly systemic delivery of oncolytic reovirus, in immunocompetent hosts, using …

Recent evidence suggests that mesenchymal stem cells (MSC) selectively home to tumors,
where they contribute to the formation of tumor-associated stroma. This effect can be …

Antigen-specific T cells circulate freely and accumulate specifically at sites of antigen
expression. To enhance the survival and targeting of systemically delivered viral vectors, we …