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Artemisinin-resistant malaria
NJ White, K Chotivanich - Clinical Microbiology Reviews, 2024 - journals.asm.org
The artemisinin antimalarials are the cornerstone of current malaria treatment. The
development of artemisinin resistance in Plasmodium falciparum poses a major threat to …
development of artemisinin resistance in Plasmodium falciparum poses a major threat to …
Prevalence and drivers of malaria infection among asymptomatic and symptomatic community members in five regions with varying transmission intensity in mainland …
Background Despite implementation of effective interventions in the past two decades,
malaria is still a major public health problem in Tanzania. This study assessed the …
malaria is still a major public health problem in Tanzania. This study assessed the …
High Frequency of Artemisinin Partial Resistance Mutations in the Great Lakes Region Revealed Through Rapid Pooled Deep Sequencing
N Wernsman Young, P Gashema… - The Journal of …, 2025 - academic.oup.com
Abstract Background In Africa, the first Plasmodium falciparum artemisinin partial resistance
mutation was Kelch13 (K13) 561H, detected and validated at appreciable frequency in …
mutation was Kelch13 (K13) 561H, detected and validated at appreciable frequency in …
Application of a new highly multiplexed amplicon sequencing tool to evaluate Plasmodium falciparum antimalarial resistance and relatedness in individual and …
JM Sadler, A Simkin, VPK Tchuenkam… - Frontiers in …, 2025 - frontiersin.org
Background Resistance to antimalarial drugs remains a major obstacle to malaria
elimination. Multiplexed, targeted amplicon sequencing is being adopted for surveilling …
elimination. Multiplexed, targeted amplicon sequencing is being adopted for surveilling …
Map** of the country-wide prevalence of non-malarial febrile illnesses in areas with varying malaria transmission intensities in Mainland Tanzania
SS Mandai, AJ Kisambale, DA Petro, C Bakari… - medRxiv, 2024 - medrxiv.org
Recent reports revealed a declining malaria burden, but non-malaria febrile illnesses
(NMFIs) have either remained unchanged or increased. This study assessed the country …
(NMFIs) have either remained unchanged or increased. This study assessed the country …
Performance of rapid diagnostic tests, microscopy, and qPCR for detection of parasites among community members with or without symptoms of malaria in villages …
Background Despite the implementation of different control interventions, infections in the
communities (among asymptomatic and symptomatic individuals) still play a crucial role in …
communities (among asymptomatic and symptomatic individuals) still play a crucial role in …
Rising prevalence of Plasmodium falciparum artemisinin resistance mutations in Ethiopia
Ethiopia is striving to eliminate local malaria transmission by 2030, despite a recent
resurgence of malaria cases due to multiple factors. A significant contributor to this …
resurgence of malaria cases due to multiple factors. A significant contributor to this …
Disparate co-evolution and prevalence of sulfadoxine and pyrimethamine resistance alleles and haplotypes at dhfr and dhps genes across Africa
NFD White, G Whitton, V Wasakul, L Amenga-Etego… - bioRxiv, 2024 - biorxiv.org
Abstract Sulfadoxine-pyrimethamine (SP), despite the emergence and spread of mutations
in dhfr and dhps genes associated with lower treatment efficacy, is still recommended alone …
in dhfr and dhps genes associated with lower treatment efficacy, is still recommended alone …