Mechanisms of mechanical overload-induced skeletal muscle hypertrophy: current understanding and future directions

MD Roberts, JJ McCarthy… - Physiological …, 2023 - journals.physiology.org
Mechanisms underlying mechanical overload-induced skeletal muscle hypertrophy have
been extensively researched since the landmark report by Morpurgo (1897) of “work …

Skeletal muscle quality: a biomarker for assessing physical performance capabilities in young populations

MA Naimo, AN Varanoske, JM Hughes… - Frontiers in …, 2021 - frontiersin.org
Muscle quality (MQ), defined as the amount of strength and/or power per unit of muscle
mass, is a novel index of functional capacity that is increasingly relied upon as a critical …

Skeletal muscle DNA methylation and mRNA responses to a bout of higher versus lower load resistance exercise in previously trained men

CL Sexton, JS Godwin, MC McIntosh, BA Ruple… - Cells, 2023 - mdpi.com
We sought to determine the skeletal muscle genome-wide DNA methylation and mRNA
responses to one bout of lower load (LL) versus higher load (HL) resistance exercise …

Sarcoplasmic hypertrophy in skeletal muscle: a scientific “unicorn” or resistance training adaptation?

MD Roberts, CT Haun, CG Vann, SC Osburn… - Frontiers in …, 2020 - frontiersin.org
Skeletal muscle fibers are multinucleated cells that contain mostly myofibrils suspended in
an aqueous media termed the sarcoplasm. Select evidence suggests sarcoplasmic …

Myofibril and mitochondrial area changes in type I and II fibers following 10 weeks of resistance training in previously untrained men

BA Ruple, JS Godwin, PHC Mesquita… - Frontiers in …, 2021 - frontiersin.org
Resistance training increases muscle fiber hypertrophy, but the morphological adaptations
that occur within muscle fibers remain largely unresolved. Fifteen males with minimal …

Optimizing Resistance Training for Sprint and Endurance Athletes: Balancing Positive and Negative Adaptations

B Van Hooren, P Aagaard, AJ Blazevich - Sports Medicine, 2024 - Springer
Resistance training (RT) triggers diverse morphological and physiological adaptations that
are broadly considered beneficial for performance enhancement as well as injury risk …

Different resistance exercise loading paradigms similarly affect skeletal muscle gene expression patterns of myostatin-related targets and mTORC1 signaling markers

MC McIntosh, CL Sexton, JS Godwin, BA Ruple… - Cells, 2023 - mdpi.com
Although transcriptome profiling has been used in several resistance training studies, the
associated analytical approaches seldom provide in-depth information on individual genes …

Effects of low-load resistance training with blood flow restriction on muscle fiber myofibrillar and extracellular area

CA Libardi, JS Godwin, TM Reece… - Frontiers in …, 2024 - frontiersin.org
Blood flow restriction applied during low-load resistance training (LL-BFR) induces a similar
increase in the cross-sectional area of muscle fibers (fCSA) compared to traditional high …

Myofiber hypertrophy adaptations following 6 weeks of low-load resistance training with blood flow restriction in untrained males and females

TM Reece, JS Godwin, MJ Strube… - Journal of Applied …, 2023 - journals.physiology.org
The effects of low-load resistance training with blood flow restriction (BFR) on hypertrophy of
type I/II myofibers remains unclear, especially in females. The purpose of the present study …

LAT1 protein content increases following 12 weeks of resistance exercise training in human skeletal muscle

PA Roberson, CB Mobley, MA Romero, CT Haun… - Frontiers in …, 2021 - frontiersin.org
Introduction: Amino acid transporters are essential for cellular amino acid transport and
promoting protein synthesis. While previous literature has demonstrated the association of …