Interferon-ε loss is elusive 9p21 link to immune-cold tumors, resistant to immune-checkpoint therapy and endogenous CXCL9/10 induction

X Zhao, B Liu, WN William, KM Tsanov, YJ Ho… - Journal of Thoracic …, 2024 - Elsevier
Introduction Copy-number (CN) loss of chromosome 9p, or parts thereof, impair immune
response and confer ICT resistance by direct elimination of immune-regulatory genes on this …

ProCyon: A multimodal foundation model for protein phenotypes

O Queen, Y Huang, R Calef, V Giunchiglia, T Chen… - bioRxiv, 2024 - biorxiv.org
Understanding the roles of human proteins remains a major challenge, with approximately
20% of human proteins lacking known functions and more than 40% missing context …