Most patients who die of cancer have disseminated disease that has become resistant to
multiple therapeutic modalities. Ample evidence suggests that the expression of ATP …

The efficacy of chemotherapy is one of the main challenges in cancer treatment and one of
the major obstacles to overcome in achieving lasting remission and a definitive cure in …

PURPOSE Women have more adverse events (AEs) from chemotherapy than men, but few
studies have investigated sex differences in immune or targeted therapies. We examined …

Chemotherapy remains the standard of care for most cancers worldwide, however
development of chemoresistance due to the presence of the drug-effluxing ATP binding …

Resistance to chemotherapy and molecularly targeted therapies is a major problem facing
current cancer research. The mechanisms of resistance to'classical'cytotoxic …

ATP-binding cassette (ABC) transporters are involved in active pum** of many diverse
substrates through the cellular membrane. The transport mediated by these proteins …

Multidrug resistance (MDR) is a serious problem that hampers the success of cancer
pharmacotherapy. A common mechanism is the overexpression of ATP-binding cassette …

Chemotherapeutics are the most effective treatment for metastatic tumours. However, the
ability of cancer cells to become simultaneously resistant to different drugs—a trait known as …

Effective treatment of metastatic cancers usually requires the use of toxic chemotherapy. In
most cases, multiple drugs are used, as resistance to single agents occurs almost …

▪ Abstract The design of cancer chemotherapy has become increasingly sophisticated, yet
there is no cancer treatment that is 100% effective against disseminated cancer. Resistance …