Lipid nanoparticulate drug delivery systems: recent advances in the treatment of skin disorders

SR Stefanov, VY Andonova - Pharmaceuticals, 2021 - mdpi.com
The multifunctional role of the human skin is well known. It acts as a sensory and immune
organ that protects the human body from harmful environmental impacts such as chemical …

[HTML][HTML] Clinical perspective on topical vaccination strategies

P Popova, SP Chen, S Liao, M Sadarangani… - Advanced Drug Delivery …, 2024 - Elsevier
Vaccination is one of the most successful measures in modern medicine to combat
diseases, especially infectious diseases, and saves millions of lives every year. Vaccine …

[HTML][HTML] Spanlastic-laden nanogel as a plausible platform for dermal delivery of bimatoprost with superior cutaneous deposition and hair regrowth efficiency in …

BK Almutairy, ES Khafagy, MF Aldawsari… - International Journal of …, 2024 - Elsevier
Bimatoprost (BIM) is a prostaglandin F2α analogs originally approved for the treatment of
glaucoma and ocular hypertension. Recent studies have highlighted its potential to boost …

Molecular DNA dendron vaccines

ME Distler, JP Cavaliere, MH Teplensky… - Proceedings of the …, 2023 - pnas.org
A foundational principle of rational vaccinology is that vaccine structure plays a critical role
in determining therapeutic efficacy, but in order to establish fundamental, effective, and …

[HTML][HTML] Delivery of mRNA vaccines and anti-PDL1 siRNA through non-invasive transcutaneous route effectively inhibits tumor growth

K Wang, X Wang, D Jiang, Y Pei, Z Wang… - Composites Part B …, 2022 - Elsevier
This study aimed to deliver mRNA vaccines and immune checkpoint blockers (ICB) with a
transcutaneous immunization (TCI) system based on ethosomes (ETH), exploring the …

Dermal nanomedicine: Uncovering the ability of nucleic acid to alleviate autoimmune and other related skin disorders

K Yadav, D Singh, MR Singh, S Minz, KK Sahu… - Journal of Drug Delivery …, 2022 - Elsevier
Various skin problems are affected significantly by a combination of factors that include
genetics, environmental factors, particular infections, and hitherto unexplained variables …

Responsive microneedles as a new platform for precision immunotherapy

X Liu, H Song, T Sun, H Wang - Pharmaceutics, 2023 - mdpi.com
Microneedles are a well-known transdermal or transdermal drug delivery system. Different
from intramuscular injection, intravenous injection, etc., the microneedle delivery system …

Decoy oligodeoxynucleotides: A promising therapeutic strategy for inflammatory skin disorders

M Mahjoubin-Tehran, S Rezaei, S Karav… - Human Immunology, 2024 - Elsevier
Chronic inflammatory skin conditions such as psoriasis and atopic dermatitis (AD) impose a
significant burden on both the skin and the overall well-being of individuals, leading to a …

Adjuvants in cutaneous vaccination: A comprehensive analysis

M Oladejo, AO Tijani, A Puri, L Chablani - Journal of Controlled Release, 2024 - Elsevier
Skin is the body's largest organ and serves as a protective barrier from physical, thermal,
and mechanical environmental challenges. Alongside, the skin hosts key immune system …

Pachyonychia congenita: a research agenda leading to new therapeutic approaches

EA O'Toole, DP Kelsell, MJ Caterina, M de Brito… - Journal of Investigative …, 2024 - Elsevier
Pachyonychia congenita (PC) is a dominantly inherited genetic disorder of cornification. PC
stands out among other genodermatoses because despite its rarity, it has been the focus of …