Prevalent since pre-history, human tuberculosis—caused by the pathogen Mycobacterium
tuberculosis—remains a major source of death worldwide. Moreover, increasing drug …

Approaches to the identification of metabolites have progressed from early biochemical
pathway evaluation to modern high-dimensional metabolomics, a powerful tool to identify …

Abstract Background The Direct Repeat locus of the Mycobacterium tuberculosis complex
(MTC) is a member of the CRISPR (Clustered regularly interspaced short palindromic …

Mycobacterium marinum, a ubiquitous pathogen of fish and amphibia, is a near relative of
Mycobacterium tuberculosis, the etiologic agent of tuberculosis in humans. The genome of …

Tuberculosis is an ever-changing field. The editors and authors of “Tuberculosis 2007–from
basic science to patient care” have made every effort to provide information that is accurate …

The contribution of horizontal gene transfer (HGT) to the evolution of Mycobacterium
tuberculosis—the main causal agent of tuberculosis in humans—and closely related …

Placement of the mitochondrial branch on the tree of life has been problematic. Sparse
sampling, the uncertainty of how lateral gene transfer might overwrite phylogenetic signals …

In this study, we designed and synthesized a series of coumarin derivatives as
antitubercular agents targeting the enoyl acyl carrier protein reductase (InhA) enzyme …

Two of humankind's most socially and psychologically devastating diseases, tuberculosis
and leprosy, have been the subject of intensive paleopathological research due to their …

Tuberculosis (TB) continues to be a global health crisis, necessitating urgent interventions to
address drug resistance and improve treatment efficacy. In this study, we validate lumazine …