Owing to advances in radiotherapy, the physical properties of radiation can be optimized to
enable individualized treatment; however, optimization is rarely based on biological …

Definition of the disease Ataxia telangiectasia (AT) is an autosomal recessive disorder
primarily characterized by cerebellar degeneration, telangiectasia, immunodeficiency …

Medulloblastoma (MB) comprises a biologically heterogeneous group of embryonal tumours
of the cerebellum. Four subgroups of MB have been described (WNT, sonic hedgehog …

A key challenge in radiotherapy is to maximize radiation doses to cancer cells while
minimizing damage to surrounding healthy tissue. As severe toxicity in a minority of patients …

Radiation therapy has curative or palliative potential in roughly half of all incident solid
tumours, and offers organ and function preservation in most cases. Unfortunately, early and …

Background Ataxia-telangiectasia is an autosomal recessive, multi-system, and life-
shortening disease caused by mutations in the ataxia-telangiectasia mutated gene …

Soy foods have been reported to have protective effects against premenopausal breast
cancer in Asian women. No studies have been reported on potential physiological effects of …

Radiotherapy is associated with a broad spectrum of early and late normal tissue injury. It is
a basic clinical observation that even within a group of identically treated patients large …

Adverse reactions to radiotherapy represent a confounding phenomenon in radiation
oncology. These reactions are rare, and many have been associated with individuals with …

Nijmegen breakage syndrome (NBS), a rare autosomal recessive condition also known as
ataxia telangiectasia (AT) variants V1 and V2, is characterised by microcephaly, typical …