The cyclic guanosine monophosphate (cGMP) signaling system is one of the most
prominent regulators of a variety of physiological and pathophysiological processes in many …

Cyclic nucleotide phosphodiesterases (PDEs) form an 11-member superfamily comprising
100 different isoforms that regulate the second messengers cyclic adenosine or guanosine …

Meiosis in mammalian oocytes is paused until luteinizing hormone (LH) activates receptors
in the mural granulosa cells of the ovarian follicle. Prior work has established the central role …

Abstract 3′, 5′-cyclic adenosine monophosphate (cAMP) is an ubiquitous second
messenger that regulates physiological functions by acting in distinct subcellular …

Irritable bowel syndrome (IBS) patients suffer from chronic abdominal pain and
extraintestinal comorbidities, including overactive bladder (OAB) and interstitial …

Cyclic GMP regulates multiple cell types and functions of the cardiovascular system. This
review summarizes the effects of cGMP on the growth and survival of vascular smooth …

Background and Purpose Generation of cGMP via NO‐sensitive soluble guanylyl cyclase
(sGC) has been implicated in the regulation of renal functions. Chronic kidney disease …

The second messenger cyclic guanosine monophosphate (cGMP) is an important regulator
of human (patho-) physiology and has emerged as an attractive drug target. Currently, cGMP …

Cyclic adenosine monophosphate (cAMP) is a canonical intracellular messenger playing
diverse roles in cell functions. In neurons, cAMP promotes axonal growth during early …

Mechanisms that limit thrombosis are poorly defined. One of the few known endogenous
platelet inhibitors is nitric oxide (NO). NO activates NO sensitive guanylyl cyclase (NO-GC) in …