Regulated cell death (RCD) is considered a critical pathway in cancer therapy, contributing
to eliminating cancer cells and influencing treatment outcomes. The application of RCD in …

As an emerging cancer therapeutic target, non-apoptotic cell death such as ferroptosis,
necroptosis and pyroptosis, etc., has revealed significant potential in cancer treatment for …

Ferroptosis is a nonapoptotic form of cell death characterized by iron‐dependent
accumulation of lipid hydroperoxides to lethal levels. Necroptosis, an alternative form of …

Background Berberine (BBR), a compound extracted from a variety of medicinal herbs, has
been shown multiple pharmacological effects against cancer cells of different origins …

Cancer therapy is aimed at the elimination of tumor cells and acts via the cessation of cell
proliferation and induction of cell death. Many research publications discussing the …

Necroptosis is a programmed, caspase-independent cell death that is morphologically
similar to necrosis. Unlike apoptosis, necroptosis evokes inflammatory responses by …

Cell death has a fundamental impact on the evolution of degenerative disorders,
autoimmune processes, inflammatory diseases, tumor formation and immune surveillance …

Over last decades, most antitumor therapeutic strategies have focused on apoptosis,
however, apoptosis resistance and immunological silence usually led to treatment failure. In …

Ripk3-mediated cellular apoptosis is a major contributor to the pathogenesis of myocardial
ischemia reperfusion (IR) injury. However, the mechanisms by which Ripk3 influences …

Over the past decades, promising therapies targeting different signaling pathways have
emerged. Among these pathways, apoptosis has been well investigated and targeted to …