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[HTML][HTML] Recent development on COX-2 inhibitors as promising anti-inflammatory agents: The past 10 years
Z Ju, M Li, J Xu, DC Howell, Z Li, FE Chen - Acta Pharmaceutica Sinica B, 2022 - Elsevier
Cyclooxygenases play a vital role in inflammation and are responsible for the production of
prostaglandins. Two cyclooxygenases are described, the constitutive cyclooxygenase-1 and …
prostaglandins. Two cyclooxygenases are described, the constitutive cyclooxygenase-1 and …
[HTML][HTML] An overview of the biological evaluation of selected nitrogen-containing heterocycle medicinal chemistry compounds
Heterocyclic compounds are a class of compounds of natural origin with favorable
properties and hence have major pharmaceutical significance. They have an exceptional …
properties and hence have major pharmaceutical significance. They have an exceptional …
Design, characterization and in vivo performance of solid lipid nanoparticles (SLNs)-loaded mucoadhesive buccal tablets for efficient delivery of Lornoxicam in …
Lornoxicam (LRX) is a potent nonsteroidal anti-inflammatory drug (NSAID) used extensively
to manage pain and inflammatory conditions. However, the drug possesses poor aqueous …
to manage pain and inflammatory conditions. However, the drug possesses poor aqueous …
Design, synthesis, and antiproliferative properties of new 1, 2, 3-triazole-carboximidamide derivatives as dual EGFR/VEGFR-2 inhibitors
A new series of substituted aryl carboximidamide VIa-o was designed and synthesised. IR, 1
H NMR, 13 C NMR as well as elemental microanalysis were used to confirm the structures of …
H NMR, 13 C NMR as well as elemental microanalysis were used to confirm the structures of …
A comprehensive review of recent advances in the biological activities of 1, 2, 4‐oxadiazoles
Nitrogen heterocycles play an essential role in medication development. The 1, 2, 4‐
oxadiazole heterocycle has been extensively studied, yielding a large variety of molecules …
oxadiazole heterocycle has been extensively studied, yielding a large variety of molecules …
Exploring thiazole-based Schiff base analogs as potent α-glucosidase and α-amylase inhibitor: their synthesis and in-silico study
In search of potent antidiabetic agents here in this study a new series of thiazole-based
Schiff base analogs (1–20) have been synthesized, characterized by 1 HNMR, 13 CNMR …
Schiff base analogs (1–20) have been synthesized, characterized by 1 HNMR, 13 CNMR …
[HTML][HTML] Synthesis and biological evaluation of indole-2-carboxamides with potent apoptotic antiproliferative activity as egfr/cdk2 dual inhibitors
The apoptotic antiproliferative actions of our previously reported CB1 allosteric modulators 5-
chlorobenzofuran-2-carboxamide derivatives VIIa–j prompted us to develop and synthesise …
chlorobenzofuran-2-carboxamide derivatives VIIa–j prompted us to develop and synthesise …
[HTML][HTML] A review on progress of thiazole derivatives as potential anti-inflammatory agents
Inflammation is a body response against infection that activates other biological components
that include various cytokines, chemokines and other biological compounds that trigger …
that include various cytokines, chemokines and other biological compounds that trigger …
Design and synthesis of new dihydropyrimidine/sulphonamide hybrids as promising anti-inflammatory agents via dual mPGES-1/5-LOX inhibition
A novel series of dihydropyrimidine/sulphonamide hybrids 3a–j with anti-inflammatory
properties have been developed and tested as dual mPGES-1/5-LOX inhibitors. In vitro …
properties have been developed and tested as dual mPGES-1/5-LOX inhibitors. In vitro …
Design, Synthesis, and Anti-Proliferative Action of Purine/Pteridine-Based Derivatives as Dual Inhibitors of EGFR and BRAFV600E
The investigation of novel EGFR and BRAFV600E dual inhibitors is intended to serve as
targeted cancer treatment. Two sets of purine/pteridine-based derivatives were designed …
targeted cancer treatment. Two sets of purine/pteridine-based derivatives were designed …