Patients with advanced cancer generate 4 million visits annually to emergency departments
(EDs) and other dedicated, high‐acuity oncology urgent care centers. Because of both the …

Graft versus host disease (GvHD) is the clinical condition in which bone marrow-derived
mesenchymal stromal cells (MSCs) have been most frequently studied. In this review, we …

Background Colony-stimulating factor 1 receptor (CSF1R)–dependent monocytes and
macrophages are key mediators of chronic graft-versus-host disease (GVHD), a major long …

Background Autoimmune polyendocrine syndrome type 1 (APS-1) is a life-threatening,
autosomal recessive syndrome caused by autoimmune regulator (AIRE) deficiency. In APS …

Cancer immunotherapy with chimeric antigen receptor (CAR) T cells can cause immune
effector cell-associated neurotoxicity syndrome (ICANS). However, the molecular …

Fundamental insight gained over the last decades led to the discovery of cytokines as
pivotal drivers of inflammatory diseases such as rheumatoid arthritis, psoriasis/psoriasis …

PURPOSE Chronic graft-versus-host disease (cGVHD) remains the major cause of late
morbidity after allogeneic hematopoietic cell transplantation. Colony-stimulating factor 1 …

The Janus kinase (JAK) signal transducer and activator of transcription (JAK-STAT) pathway
is an evolutionarily conserved mechanism of transmembrane signal transduction that …

Despite the remarkable success of immune checkpoint blockade (ICB) therapy, most cancer
patients still do not respond. We now find that immunotherapy can induce stem-like …

Since its discovery, the Janus kinase-signal transduction and activation of transcription (JAK-
STAT) pathway has become recognized as a central mediator of widespread and varied …