Abstract Purpose of Review The bone is able to adapt its structure to mechanical signals via
the bone remodeling process governed by mechanosensitive osteocytes. With aging, an …

Abstract Comprising~ 20% of the volume, water is a key determinant of the mechanical
behavior of cortical bone. It essentially exists in two general compartments: within pores and …

Osteocytes form an extensive cellular network throughout the hard tissue matrix of the
skeleton, which is known to regulate skeletal structure. However due to limitations in …

In bone remodeling, maturation of the newly formed osteonal tissue is associated with a
rapid primary increase followed by a slower secondary increase of mineralization. This …

The aim of comparative skeletal histology and paleohistology is to interpret the biological
characteristics and life history traits of vertebrates through the microstructure of their bones …

Nano-computed tomography (nano-CT) is an emerging, high-resolution cross-sectional
imaging technique and represents a technical advancement of the established micro-CT …

Osteocytes are the most abundant bone cells, entrapped inside the mineralized bone matrix.
They derive from osteoblasts through a complex series of morpho-functional modifications; …

There is considerable variation in the shape of osteocyte lacunae, which is likely to influence
the function of osteocytes as the professional mechanosensors of bone. In this review, we …

Micro-computed tomography (micro-CT)—a version of X-ray CT operating at high spatial
resolution—has had a considerable success for the investigation of trabecular bone micro …

A popular hypothesis explains the mechanosensitivity of bone due to osteocytes sensing the
load-induced flow of interstitial fluid squeezed through the lacunocanalicular network (LCN) …