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Adipokine dysregulation and adipose tissue inflammation in human obesity
Obesity, a worldwide epidemic, confers increased risk for multiple serious conditions,
including type 2 diabetes, cardiovascular diseases, nonalcoholic fatty liver disease and …
including type 2 diabetes, cardiovascular diseases, nonalcoholic fatty liver disease and …
Molecular and cellular heterogeneity in rheumatoid arthritis: mechanisms and clinical implications
Rheumatoid arthritis is an autoimmune disease that exhibits significant clinical
heterogeneity. There are various treatments for rheumatoid arthritis, including disease …
heterogeneity. There are various treatments for rheumatoid arthritis, including disease …
Monocytes in rheumatoid arthritis: Circulating precursors of macrophages and osteoclasts and, their heterogeneity and plasticity role in RA pathogenesis
Rheumatoid arthritis (RA) is a chronic systemic, autoimmune and inflammatory disease
represented as synovitis, pannus formation, adjacent bone erosions, and joint destruction …
represented as synovitis, pannus formation, adjacent bone erosions, and joint destruction …
Understanding the role of cytokines in the pathogenesis of rheumatoid arthritis
Rheumatoid arthritis (RA) is a chronic, inflammatory autoimmune disease of unknown
etiology. It is characterized by the presence of rheumatoid factor and anti-citrullinated …
etiology. It is characterized by the presence of rheumatoid factor and anti-citrullinated …
Rheumatoid arthritis: recent advances on its etiology, role of cytokines and pharmacotherapy
An autoimmune disease is defined as a clinical syndrome resulted from an instigation of
both T cell and B cell or individually, in the absence of any present infection or any sort of …
both T cell and B cell or individually, in the absence of any present infection or any sort of …
Interleukins, from 1 to 37, and interferon-γ: receptors, functions, and roles in diseases
Advancing our understanding of mechanisms of immune regulation in allergy, asthma,
autoimmune diseases, tumor development, organ transplantation, and chronic infections …
autoimmune diseases, tumor development, organ transplantation, and chronic infections …
LPS-induced cytokine production in human monocytes and macrophages
Lipopolysaccharide (LPS) from Gram-negative bacteria is one of the most potent innate
immune-activating stimuli known. Here we review the current understanding of LPS effects …
immune-activating stimuli known. Here we review the current understanding of LPS effects …
Cytokines in the pathogenesis of rheumatoid arthritis
Cytokines regulate a broad range of inflammatory processes that are implicated in the
pathogenesis of rheumatoid arthritis. In rheumatoid joints, it is well known that an imbalance …
pathogenesis of rheumatoid arthritis. In rheumatoid joints, it is well known that an imbalance …
Historical insights into cytokines
CA Dinarello - European journal of immunology, 2007 - Wiley Online Library
Cytokines affect nearly every biological process; these include embryonic development,
disease pathogenesis, non‐specific response to infection, specific response to antigen …
disease pathogenesis, non‐specific response to infection, specific response to antigen …
Evidence that cytokines play a role in rheumatoid arthritis
FM Brennan, IB McInnes - The Journal of clinical investigation, 2008 - jci.org
A large number of cytokines are active in the joints of patients with rheumatoid arthritis (RA).
It is now clear that these cytokines play a fundamental role in the processes that cause …
It is now clear that these cytokines play a fundamental role in the processes that cause …