Altered brain responses to alcohol-associated stimuli are a neural hallmark of alcohol-use
disorder (AUD) and a promising target for pharmacotherapy. However, findings in cue …

Given the strong evidence for neurological alterations at the basis of drug dependence,
functional magnetic resonance imaging (fMRI) represents an important tool in the clinical …

One of the major functions of the orbitofrontal cortex (OFC) is to promote flexible motivated
behavior. It is no surprise, therefore, that recent work has demonstrated a prominent impact …

Rising rates of alcohol use disorder (AUD) combined with increases in alcohol‐related liver
disease (ALD) and other liver disease have resulted in the need to develop alcohol …

Background Alcohol dependence is a devastating illness affecting a large population, and
new pharmacological treatments with good efficacy are greatly needed. One potential …

Background Cigarette smoking is one of the leading causes of early death. Varenicline
[Champix (UK), Pfizer Europe MA EEIG, Brussels, Belgium; or Chantix (USA), Pfizer Inc …

Introduction: Only a few medications are available for the treatment of alcohol use disorders
(AUDs). Areas covered: This paper discusses approved AUD medications, including the …

Alcohol use disorder (AUD), as currently defined in the Diagnostic and Statistical Manual,
5th Edition (DSM–5), is a heterogeneous disorder stemming from a complex interaction of …

The present review focuses on potential neural mechanisms underlying recovery from
psychiatric conditions characterised by impaired impulse control, specifically substance use …

Background The alcohol cue reactivity paradigm is increasingly used to screen medications
for the treatment of alcohol use disorder (AUD) and other substance use disorders. Yet, its …