Therapeutic strategies targeting inflammation and immunity in atherosclerosis: how to proceed?

SE Engelen, AJB Robinson, YX Zurke… - Nature Reviews …, 2022 - nature.com
Atherosclerosis is a chronic inflammatory disease of the arterial wall, characterized by the
formation of plaques containing lipid, connective tissue and immune cells in the intima of …

COVID-19 update: Covid-19-associated coagulopathy

RC Becker - Journal of thrombosis and thrombolysis, 2020 - Springer
The Covid-19 pandemic has introduced an array of organspecific and systemic phenotypes-
some previously observed in viral infections, including severe acute respiratory syndrome …

Systemic immune‐inflammation index (SII) predicted clinical outcome in patients with coronary artery disease

YL Yang, CH Wu, PF Hsu, SC Chen… - European journal of …, 2020 - Wiley Online Library
Background This study examines the predictive value of a novel systemic immune‐
inflammation index (SII, platelet× neutrophil/lymphocyte ratio) in coronary artery disease …

Mast cell: a multi-functional master cell

M Krystel-Whittemore, KN Dileepan… - Frontiers in …, 2016 - frontiersin.org
Mast cells are immune cells of the myeloid lineage and are present in connective tissues
throughout the body. The activation and degranulation of mast cells significantly modulates …

NADPH oxidases: an overview from structure to innate immunity-associated pathologies

A Panday, MK Sahoo, D Osorio, S Batra - Cellular & molecular …, 2015 - nature.com
Oxygen-derived free radicals, collectively termed reactive oxygen species (ROS), play
important roles in immunity, cell growth, and cell signaling. In excess, however, ROS are …

[HTML][HTML] Atherosclerosis: process, indicators, risk factors and new hopes

M Rafieian-Kopaei, M Setorki, M Doudi… - … journal of preventive …, 2014 - ncbi.nlm.nih.gov
Background: Atherosclerosis is the major cause of morbidities and mortalities worldwide. In
this study we aimed to review the mechanism of atherosclerosis and its risk factors, focusing …

Pathophysiology of native coronary, vein graft, and in-stent atherosclerosis

K Yahagi, FD Kolodgie, F Otsuka, AV Finn… - Nature Reviews …, 2016 - nature.com
Plaque rupture, usually of a precursor lesion known as a'vulnerable plaque'or'thin-cap
fibroatheroma', is the leading cause of thrombosis. Less-frequent aetiologies of coronary …

Thrombosis formation on atherosclerotic lesions and plaque rupture

L Badimon, G Vilahur - Journal of internal medicine, 2014 - Wiley Online Library
Atherosclerosis is a silent chronic vascular pathology that is the cause of the majority of
cardiovascular ischaemic events. The evolution of vascular disease involves a combination …

Methamphetamine use and cardiovascular disease: in search of answers

CG Kevil, NE Goeders, MD Woolard… - … , and vascular biology, 2019 - Am Heart Assoc
While the opioid epidemic has garnered significant attention, the use of methamphetamines
is growing worldwide independent of wealth or region. Following overdose and accidents …

The NLRP3 inflammasome and the emerging role of colchicine to inhibit atherosclerosis-associated inflammation

GJ Martinez, DS Celermajer, S Patel - Atherosclerosis, 2018 - Elsevier
Atherosclerosis is considered a chronic inflammatory disease of the arterial wall. Recently,
compelling evidence has arisen for the role of monocytes and neutrophils and a particular …