Transcriptome-wide association studies: recent advances in methods, applications and available databases
Genome-wide association study has identified fruitful variants impacting heritable traits.
Nevertheless, identifying critical genes underlying those significant variants has been a …
Nevertheless, identifying critical genes underlying those significant variants has been a …
From GWAS to gene: transcriptome-wide association studies and other methods to functionally understand GWAS discoveries
B Li, MD Ritchie - Frontiers in genetics, 2021 - frontiersin.org
Since their inception, genome-wide association studies (GWAS) have identified more than a
hundred thousand single nucleotide polymorphism (SNP) loci that are associated with …
hundred thousand single nucleotide polymorphism (SNP) loci that are associated with …
webTWAS: a resource for disease candidate susceptibility genes identified by transcriptome-wide association study
The development of transcriptome-wide association studies (TWAS) has enabled
researchers to better identify and interpret causal genes in many diseases. However, there …
researchers to better identify and interpret causal genes in many diseases. However, there …
Global Biobank Meta-analysis Initiative: Powering genetic discovery across human disease
Biobanks facilitate genome-wide association studies (GWASs), which have mapped
genomic loci across a range of human diseases and traits. However, most biobanks are …
genomic loci across a range of human diseases and traits. However, most biobanks are …
Adjusting for genetic confounders in transcriptome-wide association studies improves discovery of risk genes of complex traits
Many methods have been developed to leverage expression quantitative trait loci (eQTL)
data to nominate candidate genes from genome-wide association studies. These methods …
data to nominate candidate genes from genome-wide association studies. These methods …
SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells
Glutathione (GSH) is a small-molecule thiol that is abundant in all eukaryotes and has key
roles in oxidative metabolism. Mitochondria, as the major site of oxidative reactions, must …
roles in oxidative metabolism. Mitochondria, as the major site of oxidative reactions, must …
Role of the gut-brain axis in the shared genetic etiology between gastrointestinal tract diseases and psychiatric disorders: a genome-wide pleiotropic analysis
Importance Comorbidities and genetic correlations between gastrointestinal tract diseases
and psychiatric disorders have been widely reported, with the gut-brain axis (GBA) …
and psychiatric disorders have been widely reported, with the gut-brain axis (GBA) …
Alternative polyadenylation transcriptome-wide association study identifies APA-linked susceptibility genes in brain disorders
Alternative polyadenylation (APA) plays an essential role in brain development; however,
current transcriptome-wide association studies (TWAS) largely overlook APA in nominating …
current transcriptome-wide association studies (TWAS) largely overlook APA in nominating …
TWAS Atlas: a curated knowledgebase of transcriptome-wide association studies
Transcriptome-wide association studies (TWASs), as a practical and prevalent approach for
detecting the associations between genetically regulated genes and traits, are now leading …
detecting the associations between genetically regulated genes and traits, are now leading …
Metabolic gene function discovery platform GeneMAP identifies SLC25A48 as necessary for mitochondrial choline import
Organisms maintain metabolic homeostasis through the combined functions of small-
molecule transporters and enzymes. While many metabolic components have been well …
molecule transporters and enzymes. While many metabolic components have been well …