Glycogen synthase kinase 3β (GSK3) is a multifaceted serine/threonine (S/T) kinase
expressed in all eukaryotic cells. GSK3β is highly enriched in neurons in the central nervous …

The axon initial segment is a highly specialized neuronal compartment, identified almost 50
years ago by the pioneers of electron microscopy. Located in the first 50 μm of the axon, it …

Amyloid-beta (Aβ) plays a key role in the pathogenesis of Alzheimer's disease (AD), but little
is known about the proteoforms present in AD brain. We used high-resolution mass …

Activity-dependent plasticity of the axon initial segment (AIS) endows neurons with the ability
to adapt action potential output to changes in network activity. Action potential initiation at …

One of the main drivers of autism spectrum disorder is risk alleles within hundreds of genes,
which may interact within shared but unknown protein complexes. Here we develop a …

The voltage‐gated sodium channel NaV1. 7 plays a critical role in pain pathways. We
generated an epitope‐tagged NaV1. 7 mouse that showed normal pain behaviours to …

The finely tuned regulation of neuronal firing relies on the integrity of ion channel
macromolecular complexes. Minimal disturbances of these tightly regulated networks can …

Summary Objective Fibroblast Growth Factor 12 (FGF12) may represent an important
modulator of neuronal network activity and has been associated with developmental and …

Among the FGF proteins, the least characterized superfamily is the group of fibroblast growth
factor homologous factors (FHFs). To date, the main role of FHFs has been primarily seen in …

Human-induced pluripotent stem cells (hiPSCs) allow for the establishment of brain cellular
models of psychiatric disorders that account for a patient's genetic background. Here, we …