The burgeoning organic near-infrared (NIR) ratiometric small-molecule fluorescent probes
with excellent merits have attracted great attention over the past few years. The traditional …

Chemotherapeutic resistance poses a significant challenge in cancer treatment, resulting in
the reduced efficacy of standard chemotherapeutic agents. Abnormal metabolism …

Longitudinal multimodal imaging presents unique opportunities for noninvasive surveillance
and prediction of treatment response to cancer immunotherapy. In this work we first …

Prostate-cancer (PC) is a leading cause of cancer-related deaths in men worldwide.
Interleukin-(IL)-30 is a PC-progression driver, and its suppression would be strategic for …

Tuberculosis (TB) is a chronic systemic infectious disease caused by Mycobacterium
tuberculosis (M. tuberculosis). Methionine aminopeptidase 1 (MtMET-AP1) is a hydrolase …

Abstract Methionine aminopeptidase 2 (MetAP-2) catalyzes the removal of methionine from
the amino-terminus of proteins or peptides and is a known target for anti-tumor therapy. In …

Abstract Methionine aminopeptidase type 2 (METAP2) is a ubiquitous, evolutionarily
conserved metalloprotease fundamental to protein biosynthesis which catalyzes removal of …

Methionine aminopeptidases (MetAPs) have been investigated for decades, and
pharmacological inhibition of MetAPs has been pursued to treat diseases such as viral …

Breast carcinoma remains one of the most common and fatal cancers, and even though a
series of general therapeutic approaches have been used to treat breast cancer, their …

Pancreatic neuroendocrine tumour (pNET) patients present with non-specific symptoms
leading to delayed diagnosis which in turn impacts survival. The current gold standard …