Robustness is a ubiquitously observed property of biological systems. It is considered to be
a fundamental feature of complex evolvable systems. It is attained by several underlying …

The expression of genes is regularly characterized with respect to how much, how fast,
when and where. Such quantitative data demands quantitative models. Thermodynamic …

Praise for the first edition:… superb, beautifully written and organized work that takes an
engineering approach to systems biology. Alon provides nicely written appendices to …

By leveraging the ability of Shewanella oneidensis MR‐1 (S. oneidensis MR‐1) to
anaerobically catabolize lactate through the transfer of electrons to metal minerals for …

Microorganisms have been extensively applied as active biotherapeutic agents or drug
delivery vehicles for antitumor treatment because of their unparalleled bio-functionalities …

Modulation of bacterial chromosomal supercoiling is a function of DNA gyrase‐catalyzed
strand breakage and rejoining. This reaction is exploited by both antibiotic and proteic …

The selection-mutation-drift theory of codon usage plays a major role in the theory of
molecular evolution by explaining the co-evolution of codon usage bias and tRNA content in …

With the increasing amount of experimental data on gene expression and regulation, there
is a growing need for quantitative models to describe the data and relate them to their …

How new functions arise de novo is a fundamental question in evolution. We studied de
novo evolution of promoters in Escherichia coli by replacing the lac promoter with various …

The recent proliferation of protein interaction networks has motivated research into network
alignment: the cross-species comparison of conserved functional modules. Previous studies …